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A census of mammalian imprinting.
TLDR
There is a high level of discordance of imprinting status between the mouse and human, even when cases in which the orthologue is absent from one species are excluded, and a high proportion of imprinted genes are noncoding RNAs or genes derived by retrotransposition.
Excision and transfer of the Mesorhizobium loti R7A symbiosis island requires an integrase IntS, a novel recombination directionality factor RdfS, and a putative relaxase RlxS
TLDR
It is shown that the ICEMlSymR7AintS gene, which encodes an integrase of the phage P4 family, is required for integration and excision of the island and the presence of a plasmid with cloned island traR traI2 genes resulted in excision in all cells regardless of culture density, indicating that excision may be similarly regulated.
A LuxRI‐family regulatory system controls excision and transfer of the Mesorhizobium loti strain R7A symbiosis island by activating expression of two conserved hypothetical genes
TLDR
The data suggest that derepressed TraR in conjunction with TraI1‐synthesized 3‐oxo‐C6‐HSL regulates excision and transfer of ICEMlSymR7A through expression of msi172 and msi171.
Origin-of-transfer sequences facilitate mobilisation of non-conjugative antimicrobial-resistance plasmids in Staphylococcus aureus
TLDR
Observations suggest this relaxase-in trans mechanism of mobilisation by pWBG749-family plasmids is a common mechanism of plasmid dissemination in S. aureus.
Statin therapy causes gut dysbiosis in mice through a PXR-dependent mechanism
TLDR
This study demonstrates that statin therapy drives a profound remodelling of the gut microbiota, hepatic gene deregulation and metabolic alterations in mice through a PXR-dependent mechanism.
Assembly and transfer of tripartite integrative and conjugative genetic elements
TLDR
The discovery of symbiosis ICEs that exist as three separate chromosomal regions when integrated in their hosts, but through recombination assemble as a single circular ICE for conjugative transfer reveals mechanisms by which integrases dramatically manipulate bacterial genomes to allow cotransfer of disparate chromosome regions.
The imprinted gene and parent-of-origin effect database now includes parental origin of de novo mutations
TLDR
The addition of a catalogue of de novo mutations that show a parent-of-origin effect expands the scope of the database and provides a useful tool for examining parental origin trends for different types of spontaneous mutations.
A quorum-sensing molecule acts as a morphogen controlling gas vesicle organelle biogenesis and adaptive flotation in an enterobacterium
TLDR
It is proposed that gas vesicle biogenesis in this strain represents a distinct mechanism of mobility, regulated by oxygen availability, nutritional status, the RsmA global regulatory system, and the quorum-sensing morphogen.
Staphylococcus aureus plasmids without mobilization genes are mobilized by a novel conjugative plasmid from community isolates.
TLDR
A family of conjugative plasmids isolated from colonizing community Staphylococcus aureus is described and their ability to mobilize unrelated antimicrobial resistance/virulence plasmid functions is determined, not encoding mobilization functions.
Regulation of excision and transfer of the Mesorhizobium loti R7A symbiosis island
Description: xviii, 203 p. : ill. (some col.) ; 30 cm + 1 CD-ROM (4 3/4 in.) Notes: University of Otago department: Microbiology and Immunology. Thesis (Ph. D.)--University of Otago, 2008. Includes
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