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Pharmacological and biochemical interactions between opioids and cannabinoids.
The endogenous cannabinoid system and brain development
Cannabinoids provide neuroprotection against 6-hydroxydopamine toxicity in vivo and in vitro: Relevance to Parkinson's disease
Changes in endocannabinoid contents in the brain of rats chronically exposed to nicotine, ethanol or cocaine
Analysis of cannabinoid receptor binding and mRNA expression and endogenous cannabinoid contents in the developing rat brain during late gestation and early postnatal period
Analysis of CB1 receptor binding and mRNA expression by using autoradiography and in situ hybridization in the brain of rat fetuses and newborns shows that the endogenous cannabinoid system, constituted by endogenous ligands and receptor pathways, is present in the developing brain, which suggests a possible specific role this system in neural development.
Evaluation of the neuroprotective effect of cannabinoids in a rat model of Parkinson's disease: Importance of antioxidant and cannabinoid receptor-independent properties
Presence of cannabinoid binding sites in the brain from early postnatal ages.
- F. Rodríguez de Fonseca, J. Ramos, A. Bonnin, J. Fernández-Ruiz
- Biology, PsychologyNeuroreport
- 1 February 1993
The present study demonstrates the presence of cannabinoid receptors in the brain from early postnatal ages, exhibiting a progressive increase which maximised on days 30 or 40 and then subsequently decreased to adult values.
Sex steroid influence on cannabinoid CB(1) receptor mRNA and endocannabinoid levels in the anterior pituitary gland.
Data collectively support that expression of the CB(1) receptor gene in the anterior pituitary gland is regulated by sex steroids in both males and females and gonadal steroids appear to affect the response of this gene to chronic cannabinoid administration.
Maternal exposure to Δ9-tetrahydrocannabinol facilitates morphine self-administration behavior and changes regional binding to central μ opioid receptors in adult offspring female rats
Brain regional distribution of endocannabinoids: implications for their biosynthesis and biological function.
- T. Bisogno, F. Berrendero, V. Di Marzo
- Biology, ChemistryBiochemical and biophysical research…
- 16 March 1999
The hypothesis that, in the brain, AEA is a metabolic product of NArPE and may reach levels compatible with its proposed neuromodulatory function is supported.