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The Genome Sequence of Trypanosoma cruzi, Etiologic Agent of Chagas Disease
Although the Tritryp lack several classes of signaling molecules, their kinomes contain a large and diverse set of protein kinases and phosphatases; their size and diversity imply previously unknown interactions and regulatory processes, which may be targets for intervention.
The Aedes aegypti Toll Pathway Controls Dengue Virus Infection
It is shown that the mosquito's natural microbiota play a role in modulating the dengue virus infection, possibly through basal-level stimulation of the Toll immune pathway, as indicated by an infection-responsive regulation and functional assessment of several Toll pathway–associated genes.
Discovery of Insect and Human Dengue Virus Host Factors
This work identifies insect host factors required for DENV-2 propagation, by carrying out a genome-wide RNA interference screen in Drosophila melanogaster cells using a well-established double-stranded RNA library, and suggests new approaches to control infection in the insect vector and the mammalian host.
Reciprocal Tripartite Interactions between the Aedes aegypti Midgut Microbiota, Innate Immune System and Dengue Virus Influences Vector Competence
- J. Ramirez, J. Souza-Neto, G. Dimopoulos
- Medicine, BiologyPLoS neglected tropical diseases
- 1 March 2012
It is shown that the mosquito's microbiota influences dengue virus infection of the mosquito, which in turn activates its antibacterial responses, which influences the microbial load of the mosquitoes midgut.
Predominance of lineage I among Trypanosoma cruzi isolates from Venezuelan patients with different clinical profiles of acute Chagas’ disease
- N. Añez, G. Crisante, M. M. Teixeira
- MedicineTropical medicine & international health : TM…
- 1 December 2004
This is the first study describing predominance of T. cruzi lineage I in a large number of acute chagasic patients with distinct and well‐characterized clinical profiles and analysis of random amplified polymorphic DNA (RAPD) patterns confirmed these two groups of isolates.
Molecular karyotype of clone CL Brener chosen for the Trypanosoma cruzi genome project.
The Toll immune signaling pathway control conserved anti-dengue defenses across diverse Ae. aegypti strains and against multiple dengue virus serotypes.
Chromobacterium Csp_P Reduces Malaria and Dengue Infection in Vector Mosquitoes and Has Entomopathogenic and In Vitro Anti-pathogen Activities
This bacterium isolated from the midgut of field-caught Aedes aegypti exerts in vitro anti-Plasmodium and anti-dengue activities, which appear to be mediated through Csp_P -produced stable bioactive factors with transmission-blocking and therapeutic potential.
Transcriptomic Profiling of Diverse Aedes aegypti Strains Reveals Increased Basal-level Immune Activation in Dengue Virus-refractory Populations and Identifies Novel Virus-vector Molecular…
- S. Sim, Natapong Jupatanakul, G. Dimopoulos
- Biology, MedicinePLoS neglected tropical diseases
- 1 July 2013
The comparative transcriptome dataset not only provides valuable information about immune gene regulation and usage in natural refractoriness of mosquito populations to dengue virus but also allows us to identify new molecular interactions between the virus and its mosquito vector.
Effect of naturally occurring Wolbachia in Anopheles gambiae s.l. mosquitoes from Mali on Plasmodium falciparum malaria transmission
- F. Gomes, Bretta Hixson, C. Barillas-Mury
- Medicine, BiologyProceedings of the National Academy of Sciences
- 7 November 2017
Experimental infections indicate that wAnga-Mali infection reduces malaria transmission by a mechanism that affects sporozoites and opens the possibility of exploring the introduction of Wolbachia into natural populations of anophelines as a strategy to reduce disease transmission.