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Structure and Function of G Protein Coupled Receptors
TLDR
This review summarizes the current knowledge of the molecular mechanisms by which the GPC-Rs activate second messenger systems, and it addresses their regulation and structure.
Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes
TLDR
The entire 1,370-amino-acid sequence of the human insulin receptor precursor is deduced from a single complementary DNA clone, finding sequence homologies to human epidermal growth factor receptor and the members of the src family of oncogene products.
Sequence and functional expression of the GABAA receptor shows a ligand-gated receptor super-family
Amino-acid sequences derived from complementary DMAs encoding the α- and β-subunits of the GAB A/ benzo diazepine receptor from bovine brain show homology with other ligand-gated receptor subunits,
CALCIUM CHANNEL DIVERSITY AND NEUROTRANSMITTER RELEASE : THE OMEGA -CONOTOXINS AND OMEGA -AGATOXINS
The level of intracellular Ca regulates many cellular processes, including neurotransmitter and hormone secretion, the activity of ion channels and enzymes, cytoskeletal function, cell proliferation,
Distinct primary structures, ligand‐binding properties and tissue‐specific expression of four human muscarinic acetylcholine receptors.
TLDR
Differences among subtypes in the affinities and proportions of such sites suggest the capacity of mAChR subtypes to interact differentially with the cellular effector‐coupling apparatus.
Differential regulation of PI hydrolysis and adenylyl cyclase by muscarinic receptor subtypes
TLDR
This work has investigated the ability of each subtype to regulate PI hydrolysis and adenylyl cyclase when expressed individually in a cell lacking endogenous mAChRs and results indicate that the different receptor subtypes are functionally specialized.
Characterization of corticotropin receptors on adrenocortical cells.
TLDR
The results suggest that the adrenocortical cells contain only one class of ACTH receptors and that stimulation of a small fraction of these receptors (less than 3%) is sufficient for maximal steroidogenesis.
Antagonists of neuronal calcium channels: structure, function, and therapeutic implications.
TLDR
The structural and functional diversity of neuronal calcium channels and the therapeutic potential of antagonizing such channels are reviewed and the possibility that subtype-specific antagonists could provide novel treatments for some neuropathologies is raised.
An M2 muscarinic receptor subtype coupled to both adenylyl cyclase and phosphoinositide turnover.
TLDR
Individual subtypes of a given receptor are capable of regulating multiple effector pathways, and the more efficiently coupled adenylyl cyclase response was significantly more sensitive.
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