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Nitric oxide and cyclic GMP formation upon electrical field stimulation cause relaxation of corpus cavernosum smooth muscle.
TLDR
It is reported here that electrical field stimulation of isolated strips of rabbit corpus cavernosum promotes the endogenous formation and release of nitric oxide, nitrite, and cyclic GMP, and indicates that penile erection may be mediated by NO generated in response to nonadrenergic-noncholinergic neurotransmission. Expand
Nitric oxide as a mediator of relaxation of the corpus cavernosum in response to nonadrenergic, noncholinergic neurotransmission.
TLDR
The hypothesis that nitric oxide is involved in the nonadrenergic, noncholinergic neurotransmission that leads to the smooth-muscle relaxation in the corpus cavernosum that permits penile erection is supported. Expand
Paraneoplastic syndromes in urologic malignancy: the many faces of renal cell carcinoma.
TLDR
The proposed mechanisms of action of the many paraneoplastic syndromes associated with renal cell carcinoma are described as well as the clinical evaluation and treatment options currently available for these noteworthy disorders are outlined. Expand
Dihydrotestosterone is the active androgen in the maintenance of nitric oxide-mediated penile erection in the rat.
TLDR
Results show that DHT is the active androgen in the prevention of erectile failure seen in castrated rats, and suggest that this effect may be mediated, at least partially, by changes in nitric oxide synthase levels in the penis. Expand
L-arginine and phosphodiesterase (PDE) inhibitors counteract fibrosis in the Peyronie's fibrotic plaque and related fibroblast cultures.
TLDR
The hypothesis that the increase in NO and/or cGMP/cAMP levels by long-term administration of nitrergic agents or inhibitors of PDE, may be effective in reversing the fibrosis of PD, and more speculatively, other fibrotic conditions is supported. Expand
Effect of aging on nitric oxide-mediated penile erection in rats.
TLDR
The results indicate that aging causes an erectile failure due to factors initially independent from an impairment of penile NO synthesis but which are compounded in the very old rats by the decrease ofPenile NOS activity. Expand
Tadalafil dosed once a day in men with erectile dysfunction: a randomized, double-blind, placebo-controlled study in the US
TLDR
Tadalafil was well tolerated and significantly improved erectile function, and co-primary efficacy endpoints were change at 24 weeks in International Index of Erectile Function E Rectile Function (EF) Domain score and mean per-patient percentage ‘yes’ responses to Sexual Encounter Profile diary questions 2 and 3. Expand
Sildenafil for treatment of erectile dysfunction in men with diabetes: a randomized controlled trial. Sildenafil Diabetes Study Group.
TLDR
Oral sildenafil is an effective and well-tolerated treatment for erectile dysfunction in men with diabetes. Expand
Quercetin in men with category III chronic prostatitis: a preliminary prospective, double-blind, placebo-controlled trial.
TLDR
Therapy with the bioflavonoid quercetin is well tolerated and provides significant symptomatic improvement in most men with chronic pelvic pain syndrome. Expand
Current treatment options for penile fractures.
TLDR
Although a majority of cases can be diagnosed from the history and physical examination alone, radiographic studies, including retrograde urethrography and corporal cavernosography can aid in the diagnosis of unusual cases. Expand
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