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- Publications
- Influence
Small molecule BDNF mimetics activate TrkB signaling and prevent neuronal degeneration in rodents.
- S. Massa, T. Yang, +6 authors F. Longo
- Biology, Medicine
- The Journal of clinical investigation
- 3 May 2010
Brain-derived neurotrophic factor (BDNF) activates the receptor tropomyosin-related kinase B (TrkB) with high potency and specificity, promoting neuronal survival, differentiation, and synaptic… Expand
Blocking Macrophage Leukotriene B4 Prevents Endothelial Injury and Reverses Pulmonary Hypertension
- Wen Tian, X. Jiang, +13 authors M. Nicolls
- Biology, Medicine
- Science Translational Medicine
- 28 August 2013
In a rat model of pulmonary hypertension, inhibition of LTB4 synthesis in macrophages that accumulate in lung tissue reverses the disease. How to Open a Blocked Vessel Like the pressure that builds… Expand
Enhancement of mesenchymal stem cell angiogenic capacity and stemness by a biomimetic hydrogel scaffold.
- K. Rustad, Victor W. Wong, +5 authors Geoffrey C. Gurtner
- Biology, Medicine
- Biomaterials
- 2012
In this study, we examined the capacity of a biomimetic pullulan-collagen hydrogel to create a functional biomaterial-based stem cell niche for the delivery of mesenchymal stem cells (MSCs) into… Expand
Small Molecule, Non-Peptide p75NTR Ligands Inhibit Aβ-Induced Neurodegeneration and Synaptic Impairment
- T. Yang, J. Knowles, +11 authors F. Longo
- Biology, Medicine
- PloS one
- 3 November 2008
The p75 neurotrophin receptor (p75NTR) is expressed by neurons particularly vulnerable in Alzheimer's disease (AD). We tested the hypothesis that non-peptide, small molecule p75NTR ligands found to… Expand
The p75 Neurotrophin Receptor Promotes Amyloid-β(1-42)-Induced Neuritic Dystrophy In Vitro and In Vivo
- J. Knowles, J. Rajadas, +7 authors F. Longo
- Biology, Medicine
- The Journal of Neuroscience
- 26 August 2009
Oligomeric forms of amyloid-β (Aβ) are thought to play a causal role in Alzheimer's disease (AD), and the p75 neurotrophin receptor (p75NTR) has been implicated in Aβ-induced neurodegeneration. To… Expand
Neuroprotective natural antibodies to assemblies of amyloidogenic peptides decrease with normal aging and advancing Alzheimer's disease
- M. Britschgi, C. E. Olin, +21 authors T. Wyss-Coray
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 21 July 2009
A number of distinct β-amyloid (Aβ) variants or multimers have been implicated in Alzheimer's disease (AD), and antibodies recognizing such peptides are in clinical trials. Humans have natural… Expand
The effect of bioengineered acellular collagen patch on cardiac remodeling and ventricular function post myocardial infarction.
- Vahid Serpooshan, M. Zhao, +9 authors P. Ruiz-Lozano
- Medicine
- Biomaterials
- 1 December 2013
Regeneration of the damaged myocardium is one of the most challenging fronts in the field of tissue engineering due to the limited capacity of adult heart tissue to heal and to the mechanical and… Expand
A critical role for the PAR-1/MARK-tau axis in mediating the toxic effects of Aβ on synapses and dendritic spines.
- Wendou Yu, J. Polepalli, D. Wagh, J. Rajadas, R. Malenka, B. Lu
- Biology, Medicine
- Human molecular genetics
- 15 March 2012
Alzheimer's disease (AD) is the most common neurodegenerative disease and the leading cause of dementia in the elderly. Accumulating evidence supports soluble amyloid-β (Aβ) oligomers as the leading… Expand
Filamentous Bacteriophage Promote Biofilm Assembly and Function.
- Patrick R Secor, J. Sweere, +13 authors P. Bollyky
- Biology, Medicine
- Cell host & microbe
- 11 November 2015
Biofilms-communities of bacteria encased in a polymer-rich matrix-confer bacteria with the ability to persist in pathologic host contexts, such as the cystic fibrosis (CF) airways. How bacteria… Expand
Chaperone Activity of Small Heat Shock Proteins Underlies Therapeutic Efficacy in Experimental Autoimmune Encephalomyelitis*
- M. P. Kurnellas, S. Brownell, +11 authors J. Rothbard
- Biology, Medicine
- The Journal of Biological Chemistry
- 6 September 2012
Background: The small heat shock protein, HspB5, is therapeutic in experimental autoimmune encephalomyelitis. Results: Eight other human sHsps, a mycobacterial sHsp, and a linear peptide from HspB5… Expand