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Small molecule BDNF mimetics activate TrkB signaling and prevent neuronal degeneration in rodents.
TLDR
It is proposed that these compounds constitute a novel group of tools for the study of TrkB signaling and may provide leads for developing new therapeutic agents for neurodegenerative diseases.
Blocking Macrophage Leukotriene B4 Prevents Endothelial Injury and Reverses Pulmonary Hypertension
TLDR
The authors found that damping down excess LTB4 by inhibiting its biosynthesis could reverse disease: in treated animals, cardiac function improved and obstructed arterioles opened, and the authors uncovered a possible role for macrophage-derived LTB 4 in PH pathogenesis and identify a pathway that may be amenable to therapeutic targeting.
Small Molecule, Non-Peptide p75NTR Ligands Inhibit Aβ-Induced Neurodegeneration and Synaptic Impairment
TLDR
These studies support an extensive intersection between p75NTR signaling and Aβ pathogenic mechanisms, and introduce a class of specific small molecule ligands with the unique ability to block multiple fundamental AD-related signaling pathways, reverse synaptic impairment and inhibit Aβ-induced neuronal dystrophy and death.
The p75 Neurotrophin Receptor Promotes Amyloid-β(1-42)-Induced Neuritic Dystrophy In Vitro and In Vivo
TLDR
Findings indicate that although p75NTR likely does not mediate all Aβ effects, it does play a significant role in enabling Aβ-induced neurodegeneration in vitro and in vivo, establishing p 75NTR as an important therapeutic target for AD.
Neuroprotective natural antibodies to assemblies of amyloidogenic peptides decrease with normal aging and advancing Alzheimer's disease
TLDR
The findings support the concept of conformation-specific, cross-reactive antibodies that may protect against amyloidogenic toxic peptides and stimulating the production of such neuroprotective antibodies or passively administering them to the elderly population may provide a preventive measure toward AD.
Vascular anastomosis using controlled phase transitions in poloxamer gels
TLDR
A new method of sutureless and atraumatic vascular anastomosis is developed that uses US Food and Drug Administration-approved thermoreversible tri-block polymers to temporarily maintain an open lumen for precise approximation with commercially available glues and has potential for improving efficiency and outcomes in the surgical treatment of cardiovascular disease.
A critical role for the PAR-1/MARK-tau axis in mediating the toxic effects of Aβ on synapses and dendritic spines.
TLDR
A critical role for PAR-1/MARK kinases in AD pathogenesis is revealed and inhibitors of these kinases are suggested as potential therapeutics for AD and possibly other tauopathies where aberrant tau hyperphosphorylation is involved.
Transdermal deferoxamine prevents pressure-induced diabetic ulcers
TLDR
It is found that transdermal delivery of DFO provides a targeted means to both prevent ulcer formation and accelerate diabetic wound healing with the potential for rapid clinical translation.
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