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Six patients of Dutch ancestry with a long history of recurrent attacks of fever of unknown cause were found to have a high serum IgD level and a large number of plasma cells with cytoplasmic IgD inExpand
Galactose-deficient IgA1 in sera of IgA nephropathy patients is present in complexes with IgG.
Increased reactivity of intact or de-sialylated serum IgA1 with N-acetylgalactosamine (GalNAc)-specific lectins, Helix aspersa (HAA) and Caragana arborescens (CAA) indicated that the Gal deficiency is in glycans located in the hinge region of IgA 1 molecules. Expand
DNA vaccines with single-chain Fv fused to fragment C of tetanus toxin induce protective immunity against lymphoma and myeloma
Findings indicate that fusion to a pathogen sequence allows a tumor antigen to engage diverse immune mechanisms that suppress growth. Expand
Evaluation of monoclonal antibodies with specificity for human IgA, IgA subclasses and allotypes and secretory component. Results of an IUIS/WHO collaborative study.
The IgA- and SC-specific McAbs identified in this international collaborative study have potential as immunochemical reference reagents to identify and quantitate monomeric and polymeric IgA in human serum and secretions. Expand
Evaluation of monoclonal antibodies having specificity for human IgG subclasses: results of the 2nd IUIS/WHO collaborative study.
It appears to be inherent in the nature of the epitopes (allotopes) recognized that it will take several years before reagents applicable to a wide range of techniques will become available. Expand
Distribution of IgA1-, IgA2-, and J chain-containing cells in human tissues.
Idiopathic paraproteinemia. II. Transplantation of the paraprotein-producing clone from old to young C57BL/KaLwRij mice.
Findings indicate that IP represents in its final stage in the aging C57BL mice an intrinsic cellular defect within the affected B cell clone, which is, however, different from that found in B cell malignancies. Expand
Animal model of human disease. Multiple myeloma.
Animal models of spontaneous and induced plasmacytomas in some inbred strains of mice have proven to be useful tools for different studies on tumorigenesis and immunoregulation, but cannot be compared with the most frequent plasma cell malignancy in humans, the multiple myeloma. Expand
Organ involvement and phenotypic adhesion profile of 5T2 and 5T33 myeloma cells in the C57BL/KaLwRij mouse.
Both lines of 5T2 multiple myeloma and 5T33 MM have a phenotypic adhesion profile analogous to that of human MM cells, which concludes that the former cell line induces myel cancer development similar to the human disease. Expand
A murine model of human myeloma bone disease.
A cell line from this murine myeloma is established and subcloned and it is found that it causes osteolytic bone lesions in mice characteristic of humanMyeloma bone disease, and the bone lesions are characterized by increased osteoclast activity. Expand