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Obesity resistance and multiple mechanisms of triglyceride synthesis in mice lacking Dgat
Triglycerides (or triacylglycerols) represent the major form of stored energy in eukaryotes. Triglyceride synthesis has been assumed to occur primarily through acyl CoA:diacylglycerol transferaseExpand
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Radiation-Induced Cognitive Impairments are Associated with Changes in Indicators of Hippocampal Neurogenesis
Abstract Raber, J., Rola, R., LeFevour, A., Morhardt, D., Curley, J., Mizumatsu, S., VandenBerg, S. R. and Fike, J. R. Radiation-Induced Cognitive Impairments are Associated with Changes inExpand
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ApoE genotype accounts for the vast majority of AD risk and AD pathology
In this review, evidence is provided that apolipoprotein E (apoE) genotype accounts for the majority of Alzheimer's disease (AD) risk and pathology. The three major human isoforms, apoE2, apoE3, andExpand
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Loss of AKAP150 perturbs distinct neuronal processes in mice
A-Kinase Anchoring Proteins (AKAPs) ensure the fidelity of second messenger signaling events by directing protein kinases and phosphatases toward their preferred substrates. AKAP150 brings proteinExpand
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A role for glia in the progression of Rett’s syndrome
Rett’s syndrome (RTT) is an X-chromosome-linked autism spectrum disorder caused by loss of function of the transcription factor methyl-CpG-binding protein 2 (MeCP2). Although MeCP2 is expressed inExpand
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Neuronal depletion of calcium-dependent proteins in the dentate gyrus is tightly linked to Alzheimer's disease-related cognitive deficits
Transgenic mice expressing human amyloid precursor proteins (hAPP) and amyloid-β peptides (Aβ) in neurons develop phenotypic alterations resembling Alzheimer's disease (AD). The mechanisms underlyingExpand
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Isoform-specific effects of human apolipoprotein E on brain function revealed in ApoE knockout mice: increased susceptibility of females.
  • J. Raber, D. Wong, +5 authors L. Mucke
  • Medicine, Biology
  • Proceedings of the National Academy of Sciences…
  • 1 September 1998
Apolipoprotein E (apoE) mediates the redistribution of lipids among cells and is expressed at highest levels in brain and liver. Human apoE exists in three major isoforms encoded by distinct allelesExpand
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A WAVE-1 and WRP Signaling Complex Regulates Spine Density, Synaptic Plasticity, and Memory
The scaffolding protein WAVE-1 (Wiskott-Aldrich syndrome protein family member 1) directs signals from the GTPase Rac through the Arp2/3 complex to facilitate neuronal actin remodeling. TheExpand
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Irradiation attenuates neurogenesis and exacerbates ischemia‐induced deficits
Increased neurogenesis after cerebral ischemia suggests that functional recovery after stroke may be attributed, in part, to neural regeneration. In this study, we investigated the role ofExpand
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Removal of Perineuronal Nets in the Medial Prefrontal Cortex Impairs the Acquisition and Reconsolidation of a Cocaine-Induced Conditioned Place Preference Memory
Pyramidal neurons in the medial prefrontal cortex (mPFC) critically contribute to cocaine-seeking behavior in humans and rodents. Activity of these neurons is significantly modulated by GABAergic,Expand
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