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Gap Junctions and Connexin Hemichannels Underpin Hemostasis and Thrombosis
Background— Connexins are a widespread family of membrane proteins that assemble into hexameric hemichannels, also known as connexons. Connexons regulate membrane permeability in individual cells orExpand
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Amplification of human platelet activation by surface pannexin-1 channels
Pannexin‐1 (Panx1) forms an anion‐selective channel with a permeability up to ~1 kDa and represents a non‐lytic, non‐vesicular ATP release pathway in erythrocytes, leukocytes and neurons. RelatedExpand
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Evidence for shear-mediated Ca2+ entry through mechanosensitive cation channels in human platelets and a megakaryocytic cell line
The role of mechanosensitive (MS) Ca2+-permeable ion channels in platelets is unclear, despite the importance of shear stress in platelet function and life-threatening thrombus formation. WeExpand
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Regulation of Pannexin-1 channel activity.
Pannexin-1 (Panx1) forms anion-selective channels with a permeability up to 1 kDa and represents a pathway for the release of cytosolic ATP. Several structurally similar connexin (Cx) proteins haveExpand
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Transcriptomic Analysis of the Ion Channelome of Human Platelets and Megakaryocytic Cell Lines
Summary Ion channels have crucial roles in all cell types and represent important therapeutic targets. Approximately 20 ion channels have been reported in human platelets; however, no systematicExpand
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Abstract 11593: Thrombus Formation Under Flow is Inhibited by the Mechanosensitive Cation Channel Blockers GsMTx-4 Peptide and Gadolinium Chloride
Introduction: Ion channels contribute significantly to platelet physiology, including control of Ca2+ as a second messenger. Although there is a clear link between platelet activation and shear str...
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Evidence for shear mediated Ca 2 + entry through mechanosensitive cation
Ilkan, Z., Wright, J. R., Goodall, A. H., Gibbins, J. M., Jones, C. I. and Mahaut­Smith, M. P. (2017) Evidence for shear­ mediated Ca2+ entry through mechanosensitive cation channels in humanExpand
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The TICONC (Ticagrelor-Oncology) Study: Implications of P2Y12 Inhibition for Metastasis and Cancer-Associated Thrombosis
Abstract Background In cancer, platelets may facilitate metastatic spread by a number of mechanisms as well as contribute to thrombotic complications. Ticagrelor, a platelet antagonist- that blocks...
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