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- Publications
- Influence
Gap Junctions and Connexin Hemichannels Underpin Hemostasis and Thrombosis
- S. Vaiyapuri, C. Jones, +14 authors J. Gibbins
- Biology, Medicine
- Circulation
- 22 May 2012
Background— Connexins are a widespread family of membrane proteins that assemble into hexameric hemichannels, also known as connexons. Connexons regulate membrane permeability in individual cells or… Expand
Amplification of human platelet activation by surface pannexin-1 channels
- K. A. Taylor, J. R. Wright, C. Vial, R. Evans, M. Mahaut-Smith
- Biology, Medicine
- Journal of thrombosis and haemostasis : JTH
- 1 June 2014
Pannexin‐1 (Panx1) forms an anion‐selective channel with a permeability up to ~1 kDa and represents a non‐lytic, non‐vesicular ATP release pathway in erythrocytes, leukocytes and neurons. Related… Expand
Evidence for shear-mediated Ca2+ entry through mechanosensitive cation channels in human platelets and a megakaryocytic cell line
- Zeki Ilkan, J. R. Wright, A. Goodall, J. Gibbins, C. Jones, M. Mahaut-Smith
- Chemistry, Medicine
- The Journal of Biological Chemistry
- 17 April 2017
The role of mechanosensitive (MS) Ca2+-permeable ion channels in platelets is unclear, despite the importance of shear stress in platelet function and life-threatening thrombus formation. We… Expand
Regulation of Pannexin-1 channel activity.
- K. A. Taylor, J. R. Wright, M. Mahaut-Smith
- Biology, Medicine
- Biochemical Society transactions
- 1 June 2015
Pannexin-1 (Panx1) forms anion-selective channels with a permeability up to 1 kDa and represents a pathway for the release of cytosolic ATP. Several structurally similar connexin (Cx) proteins have… Expand
Transcriptomic Analysis of the Ion Channelome of Human Platelets and Megakaryocytic Cell Lines
- J. R. Wright, Stefan Amisten, A. Goodall, M. Mahaut-Smith
- Biology, Medicine
- Thrombosis and haemostasis
- 9 June 2016
Summary Ion channels have crucial roles in all cell types and represent important therapeutic targets. Approximately 20 ion channels have been reported in human platelets; however, no systematic… Expand
Abstract 11593: Thrombus Formation Under Flow is Inhibited by the Mechanosensitive Cation Channel Blockers GsMTx-4 Peptide and Gadolinium Chloride
- Zeki Ilkan, J. R. Wright, L. Francescut, A. Goodall, M. Mahaut-Smith
- Medicine
- 10 November 2015
Introduction: Ion channels contribute significantly to platelet physiology, including control of Ca2+ as a second messenger. Although there is a clear link between platelet activation and shear str...
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Evidence for shear mediated Ca 2 + entry through mechanosensitive cation
Ilkan, Z., Wright, J. R., Goodall, A. H., Gibbins, J. M., Jones, C. I. and MahautSmith, M. P. (2017) Evidence for shear mediated Ca2+ entry through mechanosensitive cation channels in human… Expand
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The TICONC (Ticagrelor-Oncology) Study: Implications of P2Y12 Inhibition for Metastasis and Cancer-Associated Thrombosis
- J. R. Wright, Meera Chauhan, +4 authors D. Adlam
- Medicine
- 1 June 2020
Abstract Background In cancer, platelets may facilitate metastatic spread by a number of mechanisms as well as contribute to thrombotic complications. Ticagrelor, a platelet antagonist- that blocks...
Regulation of pai-1 expression within an arterial thrombus
- S. Kurmani, D. Chan, R. E. Turnbull, C. Jones, J. R. Wright, A. Goodall
- Medicine
- 1 December 2012