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Localization of endoplasmic reticulum in living and glutaraldehyde-fixed cells with fluorescent dyes
Certain fluorescent dyes, previously reported to localize mitochondria, when used at higher concentrations also localize a continuous net-like structure in both living and glutaraldehyde-fixed cells.Expand
Mitochondrial and plasma membrane potentials cause unusual accumulation and retention of rhodamine 123 by human breast adenocarcinoma-derived MCF-7 cells.
Quantitative studies of MCF-7 cells and CV-1 cells using the permeant cationic compound tetraphenylphosphonium, in conjunction with fluorescence microscopy using rhodamine 123 (Rh123), indicate that the mitochondrial and plasma membrane potentials affect both uptake and retention of these compounds. Expand
Dequalinium, a topical antimicrobial agent, displays anticarcinoma activity based on selective mitochondrial accumulation.
Dqualinium is more effective than seven of eight established anticancer drugs in prolonging the survival of mice with intraperitoneally implanted mouse bladder carcinoma MB49 and inhibits the growth of subcutaneously implanted human colon carcinoma CX-1 in nude mice and recurrent rat Colon carcinoma W163 in rats. Expand
Are multiple markers the future of prostate cancer diagnostics?
Diagnostic utility is likely to be further increased by adding kallikreins, cytokines, growth factors, receptors and cellular adhesion factors to the biomarker panel. Expand
Mechanism for transcriptional action of cyclic AMP in Escherichia coli: entry into DNA to disrupt DNA secondary structure.
  • R. Ebright, J. R. Wong
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 1 July 1981
A detailed mechanism for action of cAMP (or indoleacetic acid) in Escherichia coli is proposed and marked similarities indicate an identical mechanism for the steroid hormones in eukaryotes. Expand
AA1, a newly synthesized monovalent lipophilic cation, expresses potent in vivo antitumor activity.
Compared with previously reported anticarcinoma lipophilic cations, 2,6-bis(4-amino-phenyl)-4-[4-(dimethylamino)phenyl]thiopyrylium chloride (AA1) appeared to display more effective in vivo anticarc inoma activity. Expand
Binding of 2-hydroxybenzo(a)pyrene to estrogen receptors in rat cytosol.
It is suggested that the estrogen receptor may mediate the carcinogenic effect of 2-OH-BP or of related chemicals and one possibility is that the receptor might convey 2- OH-BP to specific sites in DNA. Expand
Assembly of silkmoth chorion proteins: In vivo patterns of disulfide bond formation
Low-molecular-weight disulfide-bonded chorion protein multimers form that are soluble in the absence of a reducing agent and are good candidates as early intermediates in the assembly pathway of chorions. Expand
Radiation therapy in the management of cutaneous malignancies.
The role of radiation therapy for the treatment of cutaneous malignancies is examined, with special emphasis on the Treatment of BCC and SCC because these two carcinomas together account for more than 90% of all cutaneousmalignancies. Expand