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Synthesis and biological evaluation of the enantiomers of the potent and selective A1-adenosine antagonist 1,3-dipropyl-8-[2-(5,6-epoxynorbonyl)]-xanthine.
The individual enantiomers 8 and 12 of the potent and highly selective racemic A1-adenosine antagonist 1,3-dipropyl-8-[2-(5,6-epoxynorbornyl)]xanthine (ENX, 4) were synthesized utilizing asymmetricExpand
RS-33295-198: a novel, potent modulator of P-glycoprotein-mediated multidrug resistance.
A novel multidrug resistance modulator, RS-33295-198, circumvented drug resistance in human, mouse, and Chinese hamster cell lines overexpressing P-glycoprotein. It enhanced the antiproliferativeExpand
Synthesis of three potential inhibitors of leukotriene biosynthesis.
Two compounds are apparently stimulated, while 3 inhibited, the activity of lipoxygenase from intact human polymorphonuclear leukocytes in vitro when stimulated with Ca2+ and calcium ionophore A23187 in the presence of BSA and arachidonic acid. Expand
Methanodibenzosuberylpiperazines as potent multidrug resistance reversal agents
Abstract Annellation of a cyclopropyl group to the dibenzosuberane moiety of the prototypical agent MS-073 afforded potent multiple drug resistance modulators. The chiral differentiation observed forExpand
Synthesis of the Enantiomers of 7,8-Dimethoxy-2-phenyl-1,2,4,5-tetrahydro-3-benzazepine.
Syntheses a partir des chlorures de (R)- et (S)-O-acetylmandeloyle et d'homoveratrylamine via la cyclisation en isoquinoleine des homoveratrylamides de l'acide O-acetyl mandelique et la scission desExpand
Quinazolone derivatives as antagonists of alpha-1a / b adrenergic receptors.
Un compuesto que se ajusta a la **formula**, en la que X es carbono o nitrogeno, Y es carbono, y XY considerados juntos son dos atomos adyacentes del anillo A, siendo dicho anillo un anillo aromaticoExpand