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CP-84,657, a potent polyether anticoccidial related to portmicin and produced by Actinomadura sp.
TLDR
CP-84,657 is among the most potent anticoccidal agents known, effectively controlling the Eimeria species that are the major causative agents of chicken coccidiosis at doses of 5 mg/kg or less in feed. Expand
CP-82,009, a potent polyether anticoccidial related to septamycin and produced by Actinomadura sp.
TLDR
CP-82,009 is among the most potent anticoccidial agents known, effectively controlling the Eimeria species that are the major causative agents of chicken coccidiosis at doses of 5 mg/kg or less in feed. Expand
Endusamycin, a novel polycyclic ether antibiotic produced by a strain of Streptomyces endus subsp. aureus.
TLDR
Endusamycin exhibited; antibacterial activity, in vitro against Gram-positive and anaerobic bacteria, effectiveness against coccidia in poultry, and stimulation of propionic acid production in an in vitro system. Expand
CP-82,996, a novel diglycoside polyether antibiotic related to monensin and produced byActinomadura sp.
TLDR
CP-82,996 is active against certain Gram-positive bacteria, and is a very potent anticoccidial agent that effectively controlled chicken coccidiosis caused by several Eimeria species at 5–10 ppm in feed, and are 10–20 times more potent than monensin. Expand
CP-78,545, a new monocarboxylic acid ionophore antibiotic related to zincophorin and produced by a Streptomyces.
TLDR
CP-78,545, i.e., 24-dehydrozincophorin, is unique since its molecular backbone contains a terminal double bond previously not found in other polyether ionophores. Expand
CP-91,243 and CP-91,244, novel diglycoside polyether antibiotics related to UK-58,852 and produced by mutants of Actinomadura roseorufa.
TLDR
The two compounds differ from each other in that the A-ring glycone of UK-58,852 has been replaced by a hydroxyl group in semduramicin (Fig1). Expand
CP-61,405, a novel polycyclic pyrrolether antibiotic produced byStreptomyces routienii Huang sp. nov.
TLDR
CP-61,405 was co-produced with the polycyclic ether antibiotics salinomycin and epi-17-deoxy-(0–8)-salinomycin, and exhibited activity in vitro against gram-positive and anaerobic bacteria, efficacy against poultry coccidia and stimulation in vitro of propionic acid production. Expand
CP-60,993, a new dianemycin-like ionophore produced byStreptomyces hygroscopicus ATCC 39305: fermentation, isolation and characterization
TLDR
CP-60,993, 19-epi-dianemycin, is a novel polycyclic ether antibiotic produced by Streptomyces hygroscopicus ATCC 39305 and exhibited activity in vitro against Gram-positive and anaerobic bacteria, efficacy against Eimeria coccidia in vivo in poultry, and stimulation in vitro of rumen propionic acid production. Expand