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PPARα/γ dual agonists are new compounds for the treatment of diabetes mellitus. This study aimed to investigate safety, tolerability, and pharmacokinetics of CKD‐501, a novel PPARα/γ dual agonist.
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Voglibose is alpha‐glucosidase inhibitor. Due to negligible oral absorption, measuring drug concentration in the blood is impractical. So we proposed the pharmacodynamic assessment method to reflectExpand
Pregabalin has pain‐relieving, anxiolytic, and anticonvulsant activity. Our objective was to determine the pharmacokinetic characteristics, safety, and tolerance of rising, single oral doses ofExpand
YKP1358 is a novel D2 antagonist. We conducted a D2 receptor occupancy study with YKP1358 in healthy Korean male volunteers using PET, to measure the D2 occupancy and how it relates to plasma drugExpand
Lonicera japonica (LJ) has been applied to treatment of inflammatory diseases in Oriental medicine. We studied safety, tolerability, and pharmacokinetics of rising, single and multiple intravenousExpand