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Mechanistic Understanding of Lanthipeptide Biosynthetic Enzymes
Lanthipeptides are ribosomally synthesized and post-translationally modified peptides (RiPPs) that display a wide variety of biological activities, from antimicrobial to antiallodynic. LanthipeptidesExpand
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Xylan utilization in human gut commensal bacteria is orchestrated by unique modular organization of polysaccharide-degrading enzymes
Significance Fermentation of dietary fiber in the lower gut of humans is a critical process for the function and integrity of both the bacterial community and host cells. Here we demonstrate that twoExpand
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Discovery of a new ATP-binding motif involved in peptidic azoline biosynthesis
Despite intensive research, the cyclodehydratase responsible for azoline biogenesis in thiazole/oxazole-modified microcin (TOMM) natural products remains enigmatic. The collaboration of two proteins,Expand
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Biosynthesis of the neurotoxin domoic acid in a bloom-forming diatom
How algae turn tides toxic Algal blooms can devastate marine mammal communities through the production of neurotoxins that accumulate within the food web. Brunson et al. identified a cluster of genesExpand
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Structural and Biochemical Basis for Mannan Utilization by Caldanaerobius polysaccharolyticus Strain ATCC BAA-17*
Background: The thermophilic bacterium Caldanaerobius polysaccharolyticus can utilize mannan polysaccharides found in plant hemicellulose. Results: The mannan degradation gene cluster contains aExpand
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Characterization of the macrocyclase involved in the biosynthesis of RiPP cyclic peptides in plants
Significance The class of bioactive cyclic plant natural products called orbitides was first identified nearly half a century ago. Here we describe how a single enzyme can catalyze the cyclization ofExpand
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Scalable Biosynthesis of the Seaweed Neurochemical, Kainic Acid.
Kainic acid, the flagship member of the kainoid family of natural neurochemicals, is a widely used neuropharmacological agent that helped unravel the key role of ionotropic glutamate receptors,Expand
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Biosynthesis of l-4-Chlorokynurenine, an Antidepressant Prodrug and a Non-Proteinogenic Amino Acid Found in Lipopeptide Antibiotics.
l-4-Chlorokynurenine (l-4-Cl-Kyn) is a neuropharmaceutical drug candidate that is in development for the treatment of major depressive disorder. Recently, this amino acid was naturally found as aExpand
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Structure of the Lasso Peptide Isopeptidase Identifies a Topology for Processing Threaded Substrates.
Lasso peptides are a class of bioactive ribosomally synthesized and post-translationally modified peptides (RiPPs), with a threaded knot structure that is formed by an isopeptide bond attaching theExpand
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Molecular Basis for Resistance Against Phosphonate Antibiotics and Herbicides.
Research in recent years have illuminated data on the mechanisms and targets of phosphonic acid antibiotics and herbicides, including fosfomycin, glyphosate, fosmidomycin and FR900098. Here we reviewExpand
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