Author pages are created from data sourced from our academic publisher partnerships and public sources.
- Publications
- Influence
Mechanistic Understanding of Lanthipeptide Biosynthetic Enzymes
- Lindsay M. Repka, J. R. Chekan, S. K. Nair, W. A. van der Donk
- Chemistry, Medicine
- Chemical reviews
- 30 January 2017
Lanthipeptides are ribosomally synthesized and post-translationally modified peptides (RiPPs) that display a wide variety of biological activities, from antimicrobial to antiallodynic. Lanthipeptides… Expand
Xylan utilization in human gut commensal bacteria is orchestrated by unique modular organization of polysaccharide-degrading enzymes
- M. Zhang, J. R. Chekan, +6 authors I. Cann
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 18 August 2014
Significance Fermentation of dietary fiber in the lower gut of humans is a critical process for the function and integrity of both the bacterial community and host cells. Here we demonstrate that two… Expand
Discovery of a new ATP-binding motif involved in peptidic azoline biosynthesis
- K. Dunbar, J. R. Chekan, C. L. Cox, Brandon Burkhart, S. Nair, D. Mitchell
- Biology, Medicine
- Nature chemical biology
- 19 July 2014
Despite intensive research, the cyclodehydratase responsible for azoline biogenesis in thiazole/oxazole-modified microcin (TOMM) natural products remains enigmatic. The collaboration of two proteins,… Expand
Biosynthesis of the neurotoxin domoic acid in a bloom-forming diatom
- John K Brunson, Shaun M. K. McKinnie, +10 authors B. Moore
- Biology, Medicine
- Science
- 28 September 2018
How algae turn tides toxic Algal blooms can devastate marine mammal communities through the production of neurotoxins that accumulate within the food web. Brunson et al. identified a cluster of genes… Expand
Structural and Biochemical Basis for Mannan Utilization by Caldanaerobius polysaccharolyticus Strain ATCC BAA-17*
- J. R. Chekan, I. H. Kwon, +5 authors S. Nair
- Biology, Medicine
- The Journal of Biological Chemistry
- 23 October 2014
Background: The thermophilic bacterium Caldanaerobius polysaccharolyticus can utilize mannan polysaccharides found in plant hemicellulose. Results: The mannan degradation gene cluster contains a… Expand
Characterization of the macrocyclase involved in the biosynthesis of RiPP cyclic peptides in plants
- J. R. Chekan, P. Estrada, P. Covello, S. Nair
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 5 June 2017
Significance The class of bioactive cyclic plant natural products called orbitides was first identified nearly half a century ago. Here we describe how a single enzyme can catalyze the cyclization of… Expand
Scalable Biosynthesis of the Seaweed Neurochemical, Kainic Acid.
- J. R. Chekan, Shaun M. K. McKinnie, Malia L. Moore, Shane G Poplawski, T. Michael, B. Moore
- Biology, Medicine
- Angewandte Chemie
- 17 June 2019
Kainic acid, the flagship member of the kainoid family of natural neurochemicals, is a widely used neuropharmacological agent that helped unravel the key role of ionotropic glutamate receptors,… Expand
Biosynthesis of l-4-Chlorokynurenine, an Antidepressant Prodrug and a Non-Proteinogenic Amino Acid Found in Lipopeptide Antibiotics.
- Hanna Luhavaya, Renata Sigrist, J. R. Chekan, Shaun M. K. McKinnie, B. Moore
- Chemistry, Medicine
- Angewandte Chemie
- 17 June 2019
l-4-Chlorokynurenine (l-4-Cl-Kyn) is a neuropharmaceutical drug candidate that is in development for the treatment of major depressive disorder. Recently, this amino acid was naturally found as a… Expand
Structure of the Lasso Peptide Isopeptidase Identifies a Topology for Processing Threaded Substrates.
- J. R. Chekan, Joseph D Koos, Chuhan Zong, M. O. Maksimov, A. Link, S. Nair
- Chemistry, Medicine
- Journal of the American Chemical Society
- 7 December 2016
Lasso peptides are a class of bioactive ribosomally synthesized and post-translationally modified peptides (RiPPs), with a threaded knot structure that is formed by an isopeptide bond attaching the… Expand
Molecular Basis for Resistance Against Phosphonate Antibiotics and Herbicides.
- J. R. Chekan, D. Cogan, S. Nair
- Biology, Medicine
- MedChemComm
- 20 January 2016
Research in recent years have illuminated data on the mechanisms and targets of phosphonic acid antibiotics and herbicides, including fosfomycin, glyphosate, fosmidomycin and FR900098. Here we review… Expand