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Clinical epidemiology of the global expansion of Klebsiella pneumoniae carbapenemases.
Klebsiella pneumoniae carbapenemases (KPCs) were originally identified in the USA in 1996. Since then, these versatile β-lactamases have spread internationally among Gram-negative bacteria,Expand
Genetic Structures at the Origin of Acquisition of the β-Lactamase blaKPC Gene
ABSTRACT Genetic structures surrounding the carbapenem-hydrolyzing Ambler class A blaKPC gene were characterized in several KPC-positive Klebsiella pneumoniae and Pseudomonas aeruginosa strainsExpand
Enterobacter bacteremia: clinical features and emergence of antibiotic resistance during therapy.
OBJECTIVES To study the effect of previously administered antibiotics on the antibiotic susceptibility profile of Enterobacter, the factors affecting mortality, and the emergence of antibioticExpand
Worldwide Diversity of Klebsiella pneumoniae That Produce β-Lactamase blaKPC-2 Gene1
TOC summary: Clones harboring different plasmids with identical genetic structure could be the origin of worldwide spread.
Antibiotic resistance among gram-negative bacilli in US intensive care units: implications for fluoroquinolone use.
CONTEXT Previous surveillance studies have documented increasing rates of antimicrobial resistance in US intensive care units (ICUs) in the early 1990s. OBJECTIVES To assess national rates ofExpand
Multiple antibiotic-resistant Klebsiella and Escherichia coli in nursing homes.
CONTEXT Infections caused by ceftazidime sodium-resistant gram-negative bacteria that harbor extended-spectrum beta-lactamases (ESBLs) are increasing in frequency in hospitals in the United States.Expand
First Detection of the Plasmid-Mediated Class A Carbapenemase KPC-2 in Clinical Isolates of Klebsiella pneumoniae from South America
ABSTRACT The plasmid-mediated class A carbapenemase KPC-2 was isolated from unrelated Klebsiella pneumoniae isolates in Medellin, Colombia. These KPC enzymes are the first from South America and theExpand
Infections due to vancomycin-resistant Enterococcus faecium resistant to linezolid
Linezolid is a new oxazolidinone antibiotic used to treat infections caused by vancomycin-resistant enterococci (VRE). In early clinical trials, emergence of resistance occurred rarely. We reportExpand
Is there a common water-activity limit for the three domains of life?
Archaea and Bacteria constitute a majority of life systems on Earth but have long been considered inferior to Eukarya in terms of solute tolerance. Whereas the most halophilic prokaryotes are knownExpand
Acquisition of a natural resistance gene renders a clinical strain of methicillin‐resistant Staphylococcus aureus resistant to the synthetic antibiotic linezolid
Linezolid, which targets the ribosome, is a new synthetic antibiotic that is used for treatment of infections caused by Gram‐positive pathogens. Clinical resistance to linezolid, so far, has beenExpand