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Clinical epidemiology of the global expansion of Klebsiella pneumoniae carbapenemases.
Genetic Structures at the Origin of Acquisition of the β-Lactamase blaKPC Gene
ABSTRACT Genetic structures surrounding the carbapenem-hydrolyzing Ambler class A blaKPC gene were characterized in several KPC-positive Klebsiella pneumoniae and Pseudomonas aeruginosa strains
Enterobacter bacteremia: clinical features and emergence of antibiotic resistance during therapy.
TLDR
More judicious use of third-generation cephalosporins may decrease the incidence of nosocomial multiresistant Enterobacter spp.
Worldwide Diversity of Klebsiella pneumoniae That Produce β-Lactamase blaKPC-2 Gene
TOC summary: Clones harboring different plasmids with identical genetic structure could be the origin of worldwide spread.
Antibiotic resistance among gram-negative bacilli in US intensive care units: implications for fluoroquinolone use.
TLDR
The increasing incidence of ciprofloxacin resistance among gram-negative bacilli that has occurred coincident with increased use of fluoroquinolones will be necessary to limit this downward trend.
Multiple antibiotic-resistant Klebsiella and Escherichia coli in nursing homes.
TLDR
Nursing home patients may be an important reservoir of ESBL-containing multiple antibiotic-resistant E coli and K pneumoniae and use of broad-spectrum oral antibiotics and probably poor infection control practices may facilitate spread of this plasmid-mediated resistance.
First Detection of the Plasmid-Mediated Class A Carbapenemase KPC-2 in Clinical Isolates of Klebsiella pneumoniae from South America
TLDR
The plasmid-mediated class A carbapenemase KPC-2 was isolated from unrelated Klebsiella pneumoniae isolates in Medellin, Colombia, becoming the first from South America and the second isolation outside of the United States.
Acquisition of a natural resistance gene renders a clinical strain of methicillin‐resistant Staphylococcus aureus resistant to the synthetic antibiotic linezolid
TLDR
It is discovered that linezolid resistance in a methicillin‐resistant Staphylococcus aureus hospital strain from Colombia is determined by the presence of the cfr gene whose product, Cfr methyltransferase, modifies adenosine at position 2503 in 23S rRNA in the large ribosomal subunit.
Is there a common water-activity limit for the three domains of life?
TLDR
Evidence that halophilic prokayotes can grow down to water activities of <0.755 and extrapolation of growth curves indicated theoretical minima down to 0.611 aw suggest that there is a common water-activity limit that is determined by physicochemical constraints for the three domains of life.
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