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Cannabidiol Reduces the Anxiety Induced by Simulated Public Speaking in Treatment-Naïve Social Phobia Patients
The increase in anxiety induced by the SPST on subjects with SAD was reduced with the use of CBD, resulting in a similar response as the HC, and no significant differences were observed between CBD and HC in SSPS-N scores or in the cognitive impairment, discomfort, and alert factors of VAMS. Expand
Effects of lithium and valproate on amphetamine-induced oxidative stress generation in an animal model of mania.
The findings suggest that lithium and valproate exert protective effects against amphetamine-induced oxidative stress in vivo, further supporting the hypothesis that oxidative stress may be associated with the pathophysiology of BD. Expand
Acute administration of ketamine induces antidepressant-like effects in the forced swimming test and increases BDNF levels in the rat hippocampus
The findings suggest that the increase of hippocampal BDNF protein levels induced by ketamine might be necessary to produce a rapid onset of antidepressant action. Expand
Changes in Antioxidant Defense Enzymes after d-amphetamine Exposure: Implications as an Animal Model of Mania
The findings suggest that amphetamine exposure is associated with an imbalance between SOD and CAT activity in the prefrontal cortex, hippocampus and striatum, in a rodent model of mania. Expand
Cognitive Dysfunction Is Sustained after Rescue Therapy in Experimental Cerebral Malaria, and Is Reduced by Additive Antioxidant Therapy
New insights are provided into the natural history of cognitive dysfunction after rescue therapy for CM that may have clinical relevance, and may also be relevant to cerebral sequelae of sepsis and other disorders. Expand
Peripheral biomarkers and illness activity in bipolar disorder.
An en bloc assessment of a set of previously described biomarkers in different mood states as well as in healthy subjects, finding several of the markers discriminated between the bipolar and control groups, especially when patients were in acute episodes. Expand
Increased oxidative stress after repeated amphetamine exposure: possible relevance as a model of mania.
Longer periods of exposure to AMPH were associated with increased oxidative stress in rat brain, adding to the notion that repeated manic episodes may be associated with greater brain damage and, therefore, poorer outcomes. Expand
Methylphenidate treatment induces oxidative stress in young rat brain
The need for further research to improve understanding of MPH effects on developing nervous system and the potential consequences in adulthood resulting from early-life drug exposure is highlighted. Expand
Role of hippocampal signaling pathways in long-term memory formation of a nonassociative learning task in the rat.
It is suggested that memory formation of spatial habituation depends on the functional integrity of NMDA and AMPA/kainate receptors and CaMKII activity in the CA1 region of the hippocampus and that the detection of spatial novelty is accompanied by the activation of at least three different hippocampal protein kinase signaling cascades. Expand
Sequential Role of Hippocampus and Amygdala, Entorhinal Cortex and Parietal Cortex in Formation and Retrieval of Memory for Inhibitory Avoidance in Rats
The hippocampus and amygdala, the entorhinal cortex and the parietal cortex participate, in that sequence, both in the formation and in the expression of memory for a step‐down inhibitory avoidanceExpand