J. Quayle

Publications61
h-index23
Citations6,433
Highly Influential Citations413
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Physiological roles and properties of potassium channels in arterial smooth muscle.
This review examines the properties and roles of the four types of K+ channels that have been identified in the cell membrane of arterial smooth muscle cells. 1) Voltage-dependent K+ (KV) channels…
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ATP-sensitive and inwardly rectifying potassium channels in smooth muscle.
TLDR
Together, KATP and KIR channels are important regulators of smooth muscle function and represent important therapeutic targets.
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Hyperpolarizing vasodilators activate ATP-sensitive K+ channels in arterial smooth muscle.
TLDR
In arterial rings the vasorelaxing actions of the drugs diazoxide, cromakalim, and pinacidil and the hyperpolarizing actions of vasoactive intestinal polypeptide and acetylcholine were blocked by inhibitors of the ATP-sensitive K+ channels, suggesting that all these agents may act through a common pathway in smooth muscle by opening ATP- sensitivity channels.
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K+ channel modulation in arterial smooth muscle.
TLDR
Arterial K+ channels are modulated by physiological vasodilators, which increase K+ channel activity, and vasoconstrictors, which decrease it, which makes important contributions to the regulation of blood flow.
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Inward rectifier K+ currents in smooth muscle cells from rat resistance-sized cerebral arteries.
TLDR
The first direct measurements of inward rectifier K+ currents in single smooth muscle cells are provided and it is shown that external barium ions are effective blockers of these currents.
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ATP‐sensitive K+ channel activation by calcitonin gene‐related peptide and protein kinase A in pig coronary arterial smooth muscle
TLDR
The findings suggest that CGRP activates coronary KATP channels through a pathway that involves adenylyl cyclase and PKA, but not PKG.
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Calcitonin gene‐related peptide activated ATP‐sensitive K+ currents in rabbit arterial smooth muscle via protein kinase A.
TLDR
The results suggest the following signal transduction scheme for activation of K+ currents by C GRP in arterial smooth muscle: (1) CGRP stimulates adenylyl cyclase, which leads to an elevation of cAMP; (2) cAMP activates protein kinase A, which opens ATP‐sensitive K+ channels.
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The properties and distribution of inward rectifier potassium currents in pig coronary arterial smooth muscle.
TLDR
It is concluded that KIR channels are present in pig coronary arteries, and that they are expressed at a higher density in small diameter arteries.
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Single calcium channel currents of arterial smooth muscle at physiological calcium concentrations.
TLDR
Contrary to earlier estimates, it is found that currents through single Ca channels in arterial smooth muscle are 0.1-0.3 pA at 2 mM Ca and physiological membrane potentials, which are relatively large and permit direct measurement of Ca channel properties under conditions that do not distort their function.
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Human Keratinocytes Release ATP and Utilize Three Mechanisms for Nucleotide Interconversion at the Cell Surface*
TLDR
The potential sources of extracellular ATP required to activate P2 receptors are identified and provided to provide better understanding of the role of nucleotides in normal epidermal homeostasis and wound healing.
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