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Physiological roles and properties of potassium channels in arterial smooth muscle.
This review examines the properties and roles of the four types of K+ channels that have been identified in the cell membrane of arterial smooth muscle cells. 1) Voltage-dependent K+ (KV) channelsExpand
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ATP-sensitive and inwardly rectifying potassium channels in smooth muscle.
The properties and roles of ATP-sensitive (KATP) and inwardly rectifying (KIR) potassium channels are reviewed. Potassium channels regulate the membrane potential of smooth muscle, which controlsExpand
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Hyperpolarizing vasodilators activate ATP-sensitive K+ channels in arterial smooth muscle.
Vasodilators are used clinically for the treatment of hypertension and heart failure. The effects of some vasodilators seem to be mediated by membrane hyperpolarization. The molecular basis of thisExpand
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K+ channel modulation in arterial smooth muscle.
Potassium channels play an essential role in the membrane potential of arterial smooth muscle, and also in regulating contractile tone. Four types of K+ channel have been described in vascular smoothExpand
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ATP‐sensitive K+ channel activation by calcitonin gene‐related peptide and protein kinase A in pig coronary arterial smooth muscle
1 We used patch clamp to study whole‐cell K+ currents activated by calcitonin gene‐related peptide (CGRP) in smooth muscle cells freshly dissociated from pig coronary arteries. 2 CGRP (50 nm)Expand
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Inward rectifier K+ currents in smooth muscle cells from rat resistance-sized cerebral arteries.
Inward rectifier K+ channels have been implicated in the control of membrane potential and external K(+)-induced dilations of small cerebral arteries. In the present study, whole cell K+ currentsExpand
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Calcitonin gene‐related peptide activated ATP‐sensitive K+ currents in rabbit arterial smooth muscle via protein kinase A.
1. Whole‐cell K+ currents activated by calcitonin gene‐related peptide (CGRP) in smooth muscle cells enzymatically isolated from rabbit mesenteric arteries were measured in the conventional andExpand
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Single calcium channel currents of arterial smooth muscle at physiological calcium concentrations.
Entry of Ca through voltage-dependent Ca channels is an important regulator of the function of smooth muscle, cardiac muscle, and neurons. Although Ca channels have been extensively studied since theExpand
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The properties and distribution of inward rectifier potassium currents in pig coronary arterial smooth muscle.
1. Whole‐cell potassium currents were studied in single smooth muscle cells enzymatically isolated from pig coronary arteries. 2. In cells isolated from small diameter branches of the left anteriorExpand
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Pharmacology of ATP-sensitive K+ currents in smooth muscle cells from rabbit mesenteric artery.
The inference that ATP-sensitive K+ (KATP) channels are involved in arterial responses to the synthetic K+ channel openers, hypoxia, adenosine, and calcitonin gene-related peptide, has relied on theExpand
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