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Fever with thrombocytopenia associated with a novel bunyavirus in China.
BACKGROUND Heightened surveillance of acute febrile illness in China since 2009 has led to the identification of a severe fever with thrombocytopenia syndrome (SFTS) with an unknown cause. Infection… Expand
Progressive degeneration of human neural stem cells caused by pathogenic LRRK2
Nuclear-architecture defects have been shown to correlate with the manifestation of a number of human diseases as well as ageing. It is therefore plausible that diseases whose manifestations… Expand
Repression of the Antioxidant NRF2 Pathway in Premature Aging
Hutchinson-Gilford progeria syndrome (HGPS) is a rare, invariably fatal premature aging disorder. The disease is caused by constitutive production of progerin, a mutant form of the nuclear… Expand
S-Nitrosylation activates Cdk5 and contributes to synaptic spine loss induced by β-amyloid peptide
- J. Qu, T. Nakamura, G. Cao, Emily A Holland, S. Mckercher, S. Lipton
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 15 August 2011
The activity of Cdk5 and its regulatory subunit p35 is thought to be important in both normal brain function and neurodegenerative disease pathogenesis. Increased Cdk5 activity, via proteolytic… Expand
Artificial MicroRNA-Mediated Virus Resistance in Plants
ABSTRACT RNA silencing in plants is a natural defense system against foreign genetic elements including viruses. This natural antiviral mechanism has been adopted to develop virus-resistant plants… Expand
Recapitulation of premature aging with iPSCs from Hutchinson-Gilford progeria syndrome
Hutchinson–Gilford progeria syndrome (HGPS) is a rare and fatal human premature ageing disease, characterized by premature arteriosclerosis and degeneration of vascular smooth muscle cells (SMCs).… Expand
A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging
Heterochromatin in aging stem cells Analysis of human aging syndromes, such as Werner syndrome (WS), may lead to greater understanding of both premature and normal aging. Zhang et al. generated… Expand
Early diagnosis of novel SFTS bunyavirus infection by quantitative real-time RT-PCR assay.
- Y. Sun, M. Liang, +15 authors D. Li
- Biology, Medicine
- Journal of clinical virology : the official…
BACKGROUND Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease recently identified to be caused by a novel bunyavirus (SFTSV). The clinical diagnosis is urgently… Expand
Host cytokine storm is associated with disease severity of severe fever with thrombocytopenia syndrome.
BACKGROUND Severe fever with thrombocytopenia syndrome (SFTS) is an emerging viral disease in China, caused by SFTS virus (SFTSV). Severe SFTS patients can quickly proceed to multiorgan dysfunction… Expand
Development of marker-free transgenic Jatropha plants with increased levels of seed oleic acid
BackgroundJatropha curcas is recognized as a new energy crop due to the presence of the high amount of oil in its seeds that can be converted into biodiesel. The quality and performance of the… Expand