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Long non-coding RNA H19 increases bladder cancer metastasis by associating with EZH2 and inhibiting E-cadherin expression.
lncRNA H19 is essential for human tumor growth. However, little is known about whether H19 regulates bladder cancer metastasis. Here we found that H19 levels are remarkably increased in bladder… Expand
Dose and time-dependent protection of the antioxidant N-l-acetylcysteine against impulse noise trauma
Noise-induced hearing loss is one of the most common causes of hearing disability, and at present there is no effective biological protection or cure. Firearms and some industrial equipment can… Expand
Downregulation of GAS5 Promotes Bladder Cancer Cell Proliferation, Partly by Regulating CDK6
Long non-coding RNAs (lncRNAs) play important roles in diverse biological processes, such as transcriptional regulation, cell growth and tumorigenesis. However, little is known about whether… Expand
CCR2 Positive Exosome Released by Mesenchymal Stem Cells Suppresses Macrophage Functions and Alleviates Ischemia/Reperfusion-Induced Renal Injury
Mesenchymal stem cells (MSCs) derived exosomes have been shown to have protective effects on the kidney in ischemia/reperfusion-induced renal injury. However, the key components in the exosomes and… Expand
Antioxidant treatment with quercetin ameliorates erectile dysfunction in streptozotocin-induced diabetic rats.
- W. Zhang, Y. Wang, +4 authors T. Bao
- Chemistry, Medicine
- Journal of bioscience and bioengineering
- 1 September 2011
Oxidative stress is demonstrated to be involved in the pathophysiological mechanism of erectile dysfunction (ED). Quercetin, a potent bioflavonoid, has been reported to have the antioxidant role. In… Expand
microRNA-495 promotes bladder cancer cell growth and invasion by targeting phosphatase and tensin homolog.
- M. Tan, X. Mu, +4 authors J. Qiu
- Biology, Medicine
- Biochemical and biophysical research…
- 5 February 2017
Accumulating evidence has linked deregulation of microRNA-495 (miR-495) to tumorigenesis; however, its function in tumor progression is controversial. This work was undertaken to explore the… Expand
Overexpression of RING box protein‐1 (RBX1) associated with poor prognosis of non‐muscle‐invasive bladder transitional cell carcinoma
RING box protein‐1 (RBX1) is a key subunit of the ubiquitin E3 ligase Skp1/Cullin1/Rbx1/F‐box protein complex. Altered expression RBX1 is shown to associate with tumorigenesis and tumor progression.… Expand
Macrophages Regulate Renal Fibrosis Through Modulating TGFβ Superfamily Signaling
Renal fibrosis is the fundamental pathway leading to end-stage renal disease, while its exact molecular basis remains incompletely elucidated. Previous studies have demonstrated that transforming… Expand
Influence of CYP3A and ABCB1 polymorphisms on cyclosporine concentrations in renal transplant recipients.
AIM Cyclosporine is a substrate of CYP3A and ABCB1. This study examined the role of CYP3A and ABCB1 polymorphisms on cyclosporine pharmacokinetics in renal transplant recipients. PATIENTS & METHODS… Expand
Downregulation of Homeodomain‐Interacting Protein Kinase‐2 Contributes to Bladder Cancer Metastasis by Regulating Wnt Signaling
Homeodomain‐interacting protein kinase‐2 (Hipk2) has been shown to have important regulatory roles in cancer biology, such as cancer cell proliferation, cell cycle, and cell invasion. However, the… Expand