• Publications
  • Influence
Store-operated calcium channels.
In electrically nonexcitable cells, Ca(2+) influx is essential for regulating a host of kinetically distinct processes involving exocytosis, enzyme control, gene regulation, cell growth andExpand
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Large Store-operated Calcium Selective Currents Due to Co-expression of Orai1 or Orai2 with the Intracellular Calcium Sensor, Stim1*
The molecular nature of store-operated Ca2+-selective channels has remained an enigma, due largely to the continued inability to convincingly demonstrate Ca2+-selective store-operated currentsExpand
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STIM1 Is a MT-Plus-End-Tracking Protein Involved in Remodeling of the ER
Stromal interaction molecule 1 (STIM1) is a transmembrane protein that is essential for store-operated Ca(2+) entry, a process of extracellular Ca(2+) influx in response to the depletion of Ca(2+)Expand
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Defective mast cell effector functions in mice lacking the CRACM1 pore subunit of store-operated calcium release–activated calcium channels
CRACM1 (also called Orai1) constitutes the pore subunit of store-operated calcium release–activated calcium channels. A point mutation in the gene encoding CRACM1 is associated with severe combinedExpand
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A model for receptor-regulated calcium entry.
  • J. Putney
  • Chemistry, Medicine
  • Cell calcium
  • 1 February 1986
A model is proposed for the mechanism by which activation of surface membrane receptors causes sustained Ca2+ entry into cells from the extracellular space. Reassessment of previously publishedExpand
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Phosphorylation of STIM1 underlies suppression of store-operated calcium entry during mitosis
In both the HTML and PDF versions of this letter, statements regarding the suppression of SOCE during mitosis have been altered as follows: on page 1465 (abstract, line 2), the following text hasExpand
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The mammalian TRPC cation channels.
Transient Receptor Potential-Canonical (TRPC) channels are mammalian homologs of Transient Receptor Potential (TRP), a Ca(2+)-permeable channel involved in the phospholipase C-regulated photoreceptorExpand
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Mechanisms of capacitative calcium entry.
Capacitative Ca(2+) entry involves the regulation of plasma membrane Ca(2+) channels by the filling state of intracellular Ca(2+) stores in the endoplasmic reticulum (ER). Several theories have beenExpand
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Spatial and temporal aspects of cellular calcium signaling
Cytosolic Ca2+ signals are often organized in complex temporal and spatial patterns, even under conditions of sustained stimulation. In this review we discuss the mechanisms and physi‐ologicalExpand
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Calcium Inhibition and Calcium Potentiation of Orai1, Orai2, and Orai3 Calcium Release-activated Calcium Channels*
The recent discoveries of Stim1 and Orai proteins have shed light on the molecular makeup of both the endoplasmic reticulum Ca2+ sensor and the calcium release-activated calcium (CRAC) channel,Expand
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