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Characterization of Neurophysiological and Behavioral Changes, MRI Brain Volumetry and 1H MRS in zQ175 Knock-In Mouse Model of Huntington's Disease
TLDR
The zQ175 KI model has robust behavioral, electrophysiological, and histopathological features that may be valuable in both furthering the understanding of HD-like pathophyisology and the evaluation of potential therapeutic strategies to slow the progression of disease. Expand
Accelerating Amyloid-β Fibrillization Reduces Oligomer Levels and Functional Deficits in Alzheimer Disease Mouse Models*
Many proteins suspected of causing neurodegenerative diseases exist in diverse assembly states. For most, it is unclear whether shifts from one state to another would be helpful or harmful. We usedExpand
Fyn Kinase Induces Synaptic and Cognitive Impairments in a Transgenic Mouse Model of Alzheimer's Disease
TLDR
Increased Fyn expression is sufficient to trigger prominent neuronal deficits in the context of even relatively moderate Aβ levels, and inhibition of Fyn activity may help counteract Aβ-induced impairments. Expand
Gender differences in the amount and deposition of amyloidβ in APPswe and PS1 double transgenic mice
TLDR
The data show that female APP/PS1 mice accumulate amyloid at an earlier age and that they build up more amyloids deposits in the hippocampus than age-matched male mice. Expand
Effects of Ovariectomy and Estrogen Treatment on Learning and Hippocampal Neurotransmitters in Mice
TLDR
New information is given about the effects of estrogen on learning and hippocampal neurotransmitters in mice and the levels of hippocampal 5-HT and its metabolite 5-HIAA were different in sham-operated than in OVX mice. Expand
Reduction in Mitochondrial Superoxide Dismutase Modulates Alzheimer's Disease-Like Pathology and Accelerates the Onset of Behavioral Changes in Human Amyloid Precursor Protein Transgenic Mice
TLDR
The results suggest that Sod2 protects the aging brain against hAPP/Aβ-induced impairments, andWhereas reductions in Sod2 would be expected to trigger or exacerbate neuronal and vascular pathology in AD, increasing Sod2 activity might be of therapeutic benefit. Expand
Effects of fimbria-fornix lesion and amyloid pathology on spatial learning and memory in transgenic APP+PS1 mice
TLDR
AP mice appear to have a selective deficit in hippocampal dependent long-term memory, as do Alzheimer patients at early stage of the disease. Expand
Accelerating amyloid-beta fibrillization reduces oligomer levels and functional deficits in Alzheimer disease mouse models.
Many proteins suspected of causing neurodegenerative diseases exist in diverse assembly states. For most, it is unclear whether shifts from one state to another would be helpful or harmful. We usedExpand
Estrogen treatment improves spatial learning in APP + PS1 mice but does not affect beta amyloid accumulation and plaque formation
TLDR
The results show that the estrogen treatment in a transgenic mouse model of Alzheimer's disease (AD) improves performance in the same learning and memory tasks as in the normal C57BL/6J mice, but the estrogen effects in these mice appeared to be unrelated to A beta-induced cognitive deficits. Expand
Hippocampal Aβ42 Levels Correlate with Spatial Memory Deficit in APP and PS1 Double Transgenic Mice
TLDR
It is shown for the first time that the age-dependent impairment in memory retention in the traditional water maze of APP + PS1 mice correlates with the amount of total Abeta in hippocampus even at a stage when the amyloid deposits cover less than 1% of the hippocampal volume. Expand
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