Share This Author
Mitochondrial dynamics: overview of molecular mechanisms
An overview of the molecular mechanisms that govern mitochondrial fission and fusion in mammals is described and several members of the machinery can undergo post-translational modifications modulating these processes.
Newly born peroxisomes are a hybrid of mitochondrial and ER-derived pre-peroxisomes
It is shown that the essential import receptors Pex3 and Pex14 target mitochondria, where they are selectively released into vesicular pre-peroxisomal structures, thereby providing full import competence in newly born peroxisomes.
SLC25A46 is required for mitochondrial lipid homeostasis and cristae maintenance and is responsible for Leigh syndrome
Results show that SLC25A46 plays a role in a mitochondrial/ER pathway that facilitates lipid transfer, and link altered mitochondrial dynamics to early‐onset neurodegenerative disease and cell fate decisions.
A Mitofusin-2–dependent inactivating cleavage of Opa1 links changes in mitochondria cristae and ER contacts in the postprandial liver
- Aditi Sood, D. Jeyaraju, L. Pellegrini
- BiologyProceedings of the National Academy of Sciences
- 28 October 2014
In vivo, mitochondria adapt to metabolic shifts through the parallel remodeling of the cristae and of the MERCs via a mechanism that degrades Opa1 in an Mfn2-dependent pathway, which was previously thought to operate independently of each other.
mTOR Controls Mitochondrial Dynamics and Cell Survival via MTFP1.
MAPL SUMOylation of Drp1 Stabilizes an ER/Mitochondrial Platform Required for Cell Death.
CCDC90A (MCUR1) is a cytochrome c oxidase assembly factor and not a regulator of the mitochondrial calcium uniporter.
Non-apoptotic roles of Bcl-2 family: the calcium connection.
New insights into the role of mitochondrial calcium homeostasis in cell migration