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Anti-phencyclidine monoclonal antibodies provide long-term reductions in brain phencyclidine concentrations during chronic phencyclidine administration in rats.
TLDR
Results indicate that anti-PCP IgG can preferentially protect the brain for approximately 4 weeks after IgG administration, even when the antibody binding capacity should have been saturated with continuously administered PCP. Expand
Ocular pharmacokinetics of besifloxacin following topical administration to rabbits, monkeys, and humans.
TLDR
The results of the current investigation provide a PK/PD-based rationale that supports the use of besifloxacin for the safe and effective treatment of ocular infections. Expand
Development of an in vivo preclinical screen model to estimate absorption and bioavailability of xenobiotics.
TLDR
The aim of this study was to develop an in vivo screening method for rapid preclinical characterization of absorption and bioavailability of large numbers of compounds using a single intraduodenal dose in a preclinical model. Expand
Concentrations of besifloxacin, gatifloxacin, and moxifloxacin in human conjunctiva after topical ocular administration
TLDR
All three fluoroquinolones were well tolerated and reached levels in the conjunctiva above the MIC90s of methicillin-sensitive S. aureus and S. epidermidis for at least 2 hours and besifloxacin had the greatest area-under-the-curve (AUC) to MIC90 ratio. Expand
Preclinical pharmacokinetics of SB-203580, a potent inhibitor of p38 mitogen-activated protein kinase
TLDR
Interspecies differences in bioavailability, and the non-linear pharmacokinetics observed in rat, highlight the importance of monitoring SB-203580 systemic exposure in parallel with the pharmacological endpoint during in vivo pharmacology studies. Expand
Topical Application of the Synthetic Triterpenoid RTA 408 Protects Mice from Radiation-Induced Dermatitis
TLDR
Improvements in the appearance of skin were manifestly visible, and data indicate that RTA 408 represents a potentially promising new therapy for the treatment of radiation-induced dermatitis. Expand
Azepanone-based inhibitors of human and rat cathepsin K.
TLDR
It is concluded that the introduction of a conformational constraint has served the dual purpose of increasing inhibitor potency by locking in a bioactive conformation as well as locking out available conformations which may serve as substrates for enzyme systems that limit oral bioavailability. Expand
Pharmacodynamics of a monoclonal antiphencyclidine Fab with broad selectivity for phencyclidine-like drugs.
TLDR
Results indicate that antibody-based medications can be developed to treat toxicity caused by classes of drugs as well as by individual drugs. Expand
A single dose of monoclonal anti-phencyclidine IgG offers long-term reductions in phencyclidine behavioral effects in rats.
TLDR
A single dose of antibody medication provided long-term reductions in drug effects and brain concentrations, beyond the expected capacity of the drug-antibody interaction, and established that neuroprotection by mAbs may have an unique mechanism of action. Expand
Development of an in vivo preclinical screen model to estimate absorption and first-pass hepatic extraction of xenobiotics. II. Use of ketoconazole to identify P-glycoprotein/CYP3A-limited
TLDR
These experiments have allowed a more complete characterization of ketoconazole as a prototypic dual Pgp/CYP3A inhibitor and its use as a tool in a preclinical setting and further demonstrate the use of the monkey to investigate the role of P-glycoprotein and CYP3A in limiting the oral bioavailability of new drug candidates. Expand
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