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Emotional and Functional Impact of Radiotherapy and Chemotherapy on Patients with Primary Breast Cancer
- D. Buick, K. Petrie, R. Booth, J. Probert, Chellaraj Benjamin, V. Harvey
- Medicine, Psychology
- 21 July 2000
The results suggest that psycho-educational interventions would be advantageous before radiotherapy begins and at discrete intervals during and after chemotherapy.
Patterns of spread of distant metastases in head and neck cancer
Ninety‐six (12.3%) of a total of 779 patients with head and neck cancer were found to have distant metastases in the period from 1955 to 1967, in a study at the Division of Radiation Therapy, Stanford University School of Medicine.
Radiation therapy in the treatment of childhood astrocytic gliomas
Improved survival rates correlated with the more benign histologic picture, and radiation therapy has a useful place in the modern management of intracranial gliomas not amenable to surgical control.
Early and late radiation changes following a second course of irradiation.
Evaluation of early vs. late reactions showed that the extent of the deformity is not governed entirely by the level of the early skin reaction; rather, it depends critically on the previous radiation history of the tissue.
Growth retardation in children after megavoltage irradiation of the spine
Twenty‐two children, under the age of 15, received complete spinal irradiation with a linear accelerator, for treatment of lymphoma, medulloblastoma, and acute lymphoblastic leukemia. Sixteen of the…
The effects of radiation therapy on bone growth.
Retardation of spinal growth was seen in children irradiated during the periods of most active bone growth, i.e., under 6 years of age and during puberty.
Half body irradiation for the palliation of bone metastases.
Half body irradiation using single large doses of photons has been reported as an effective modality for the palliation of symptoms due to widespread metastatic bone malignancy. Over a 7 year period…
Prolonged disease-free survival after one course of perioperative adjuvant chemotherapy for node-negative breast cancer.
It is concluded that chemotherapy modifies the post-operative course of node-negative breast cancer and should be regarded as the best available therapeutic approach.
Selective toxicity of nitracrine to hypoxic mammalian cells.
- W. Wilson, W. Denny, S. J. Twigden, B. Baguley, J. Probert
- Biology, ChemistryBritish Journal of Cancer
- 1 February 1984
It is proposed that the cytotoxicity of nitracrine under hypoxia is due to reductive metabolism to form an alkylating species, but that intercalation of the chromophore may enhance reactivity towards DNA and hence contribute to the marked enhancement of potency with respect to simple nitroheteroaromatic drugs.