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Proteomic analysis of exosomes secreted by human mesothelioma cells.
Exosomes are small membrane vesicles secreted into the extracellular compartment by exocytosis. Tumor exosomes may be involved in the sampling of antigens to antigen presenting cells or as decoysExpand
Segmental bronchial provocation induces nasal inflammation in allergic rhinitis patients.
Allergic rhinitis and asthma often coexist and share a genetic background. Pathophysiologic connections between the nose and lungs are still not entirely understood. This study was undertaken toExpand
Lipopolysaccharide-Induced Suppression of Airway Th2 Responses Does Not Require IL-12 Production by Dendritic Cells1
The prevalence of atopic asthma, a Th2-dependent disease, is reaching epidemic proportions partly due to improved hygiene in industrialized countries. There is an inverse correlation between theExpand
Nasal allergen provocation induces adhesion molecule expression and tissue eosinophilia in upper and lower airways.
BACKGROUND Allergic rhinitis (AR) and asthma are characterized by means of a similar inflammatory process in which eosinophils are important effector cells. The migration of eosinophils from theExpand
Airway inflammation is present during clinical remission of atopic asthma.
Symptoms of atopic asthma often disappear at puberty. However, asthmatic subjects in clinical remission will frequently have a relapse later in life. The aim of this study was to investigate whetherExpand
Polygenic control of autoimmune diabetes in nonobese diabetic mice
Partial exclusion mapping of the nonobese (NOD) diabetic mouse genome has shown linkage of diabetes to at least five different chromosomes. We have now excluded almost all of the genome for theExpand
Genetic testing in familial isolated hyperparathyroidism: unexpected results and their implications
Familial hyperparathyroidism is not uncommon in clinical endocrine practice. It encompasses a spectrum of disorders including multiple endocrine neoplasia types 1 (MEN1) and 2A,Expand
Crosses of NOD Mice With the Related NON Strain: A Polygenic Model for IDDM
Chromosome locations of non–major histocompatibility complex (MHC) genes contributing to insulin-dependent diabetes mellitus (IDDM) in mice have been determined by outcrossing NOD mice to otherExpand
Genetic analysis of autoimmune type 1 diabetes mellitus in mice
Two genes, ldd-3 and ldd-4, that influence the onset of autoimmune type 1 diabetes in the nonobese diabetic mouse have been located on chromosomes 3 and 11, outside the chromosome 17 majorExpand
Type 1 diabetes in mice is linked to the interleukin-1 receptor and Lsh/lty/Bcg genes on chromosome 1
HUMAN type 1 (insulin-dependent) diabetes is a common autoimmune disease of the insulin-producing β cells of the pancreas which is caused by both genetic and environmental factors1,2. SeveralExpand