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Implication of sperm RNAs in transgenerational inheritance of the effects of early trauma in mice
TLDR
Small non-coding RNAs (sncRNAs) are potential vectors at the interface between genes and environment and injection of sperm RNAs from traumatized males into fertilized wild-type oocytes reproduced the behavioral and metabolic alterations in the resulting offspring. Expand
Sequential transcriptional waves direct the differentiation of newborn neurons in the mouse neocortex
TLDR
Early transcriptional waves that instruct the sequence and pace of neuronal differentiation events, guiding newborn neurons toward their final fate, and contribute to a road map for the reverse engineering of specific classes of cortical neurons from undifferentiated cells are revealed. Expand
Temporal patterning of apical progenitors and their daughter neurons in the developing neocortex
TLDR
A core set of evolutionarily conserved, temporally patterned genes that sequentially unfold during development are identified that drive apical progenitors from internally directed to more exteroceptive (“extraverted”) states. Expand
Transcriptomic and anatomic parcellation of 5-HT3AR expressing cortical interneuron subtypes revealed by single-cell RNA sequencing
TLDR
Overall, this study identifies MEIS2 as a subclass-specific marker for 5-HT3AR-containing interstitial interneurons and demonstrates that the transcriptional and anatomical parcellation of cortical interneeurons is developmentally coupled. Expand
Decay-Initiating Endoribonucleolytic Cleavage by RNase Y Is Kept under Tight Control via Sequence Preference and Sub-cellular Localisation
TLDR
It is shown that RNase Y is required to initiate the major degradation pathway of about a hundred transcripts that are inaccessible to other ribonucleases, but is prevented from promiscuous activity by membrane confinement and sequence preference for guanosines. Expand
Transient Cell‐intrinsic Activity Regulates the Migration and Laminar Positioning of Cortical Projection Neurons
TLDR
Results support the idea that increased cell‐intrinsic activity during migration acts as a stop signal for migrating cortical PNs. Expand
TSS-EMOTE, a refined protocol for a more complete and less biased global mapping of transcription start sites in bacterial pathogens
TLDR
Mapping transcription start sites in four important pathogens using TSS-EMOTE, a method that works with both long and 3'-phosphorylated RNA molecules, and which incorporates Unique Molecular Identifiers (UMIs) to allow unbiased quantification, provides a multitude of important information about the regulation of gene expression, both at the transcriptional and translational level. Expand
Rifampin Resistance rpoB Alleles or Multicopy Thioredoxin/Thioredoxin Reductase Suppresses the Lethality of Disruption of the Global Stress Regulator spx in Staphylococcus aureus
TLDR
It is discovered that Spx, an RNA polymerase-interacting stress regulator implicated in many stress responses in S. aureus, including responses to oxidative and cell wall antibiotics, is essential and two mechanisms that suppress the lethality of spx disruption are described. Expand
Inter-hemispherical asymmetry in default-mode functional connectivity and BAIAP2 gene are associated with anger expression in ADHD adults
TLDR
A complex interplay between genetic vulnerability and inter-hemispherical DMN FC asymmetry plays a role in emotion regulation in adult ADHD. Expand
Borderline personality disorder and childhood maltreatment: a genome‐wide methylation analysis
TLDR
The results highlight the potentially important role played by miRNAs in the etiology of neuropsychiatric disorders such as BPD and the usefulness of using methylome‐wide association studies to uncover such candidate genes. Expand
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