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Degradation of Human Antimicrobial Peptide LL-37 by Staphylococcus aureus-Derived Proteinases
ABSTRACT Cathelicidin LL-37 is one of the few human bactericidal peptides with potent antistaphylococcal activity. In this study we examined the susceptibility of LL-37 to proteolytic degradation byExpand
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The serpin superfamily of proteinase inhibitors: structure, function, and regulation.
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Porphyromonas gingivalis in Alzheimer’s disease brains: Evidence for disease causation and treatment with small-molecule inhibitors
Gingipains from Porphyromonas gingivalis drive Alzheimer’s pathology and can be blocked with small-molecule inhibitors. Porphyromonas gingivalis, the keystone pathogen in chronic periodontitis, wasExpand
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Arginine-Specific Protease fromPorphyromonas gingivalis Activates Protease-Activated Receptors on Human Oral Epithelial Cells and Induces Interleukin-6 Secretion
ABSTRACT Periodontitis is a chronic inflammatory disease affecting oral tissues. Oral epithelial cells represent the primary barrier against bacteria causing the disease. We examined the responses ofExpand
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Purification, Characterization, and Sequence Analysis of a Potential Virulence Factor from Porphyromonas gingivalis, Peptidylarginine Deiminase
ABSTRACT The initiation and progression of adult-onset periodontitis has been associated with infection of the gingival sulcus byPorphyromonas gingivalis. This organism utilizes a multitude ofExpand
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A Potential New Pathway for Staphylococcus aureus Dissemination: The Silent Survival of S. aureus Phagocytosed by Human Monocyte-Derived Macrophages
Although considered to be an extracellular pathogen, Staphylococcus aureus is able to invade a variety of mammalian, non-professional phagocytes and can also survive engulfment by professionalExpand
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Dichotomy of gingipains action as virulence factors: from cleaving substrates with the precision of a surgeon's knife to a meat chopper-like brutal degradation of proteins.
Arguably periodontitis is the most prevalent bacteria-driven chronic inflammatory disease of the humankind. The incidence of periodontal disease has been reported to range from 30% of the populationExpand
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Role of bacterial proteinases in matrix destruction and modulation of host responses.
Recently accumulated large bodies of evidence have strongly implicated proteolytic enzymes released by subgingival plaque bacteria in the pathogenicity of periodontal disease. With regard toExpand
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Peptidylarginine deiminase from Porphyromonas gingivalis citrullinates human fibrinogen and α-enolase: implications for autoimmunity in rheumatoid arthritis.
OBJECTIVE To investigate protein citrullination by the periodontal pathogen Porphyromonas gingivalis as a potential mechanism for breaking tolerance to citrullinated proteins in rheumatoid arthritisExpand
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The role and regulation of the extracellular proteases of Staphylococcus aureus.
Staphylococcus aureus has several extracellular proteases with proposed roles in virulence. SspA (serine protease), SspB (cysteine protease) and Aur (metalloprotease) have been characterizedExpand
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