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Parallel Synthesis of 1,2,3-Thiadiazoles Employing a "Catch and Release" Strategy.
1,2,3-thiadiazoles were synthesized in parallel using a polymer sulfonyl hydrazide resin (PS-TsNHNH2) and employing a "catch and release" synthesis strategy. Resin capture of ketones synthesized from
Polymer-assisted solution-phase (PASP) Suzuki couplings employing an anthracene-tagged palladium catalyst.
The Suzuki coupling reaction can be efficiently conducted by using combinations of the anthracene-tagged Pd catalyst, polymer-supported carbonate base, and anthracenes- tagged boronic acid to yield the desired product in high purity and yield without the use of chromatography.
Stereochemical and Conformational Effects on the Cycloaromatization of Dynemicin A-Related Molecules
A series of compounds was investigated in order to determine the factors that govem the cycloaromatization reaction exhibited by dynemicin A and related molecules. It was determined that the