• Publications
  • Influence
Association of complementation group and mutation type with clinical outcome in fanconi anemia. European Fanconi Anemia Research Group.
Fanconi anemia (FA) is a clinically and genetically heterogeneous disorder. Clinical care is complicated by variable age at onset and severity of hematologic symptoms. Recent advances in theExpand
Spectrum of perforin gene mutations in familial hemophagocytic lymphohistiocytosis.
Familial hemophagocytic lymphohistiocytosis (FHL) is an autosomal recessive disease of early childhood characterized by nonmalignant accumulation and multivisceral infiltration of activated TExpand
Childhood cancer incidence in South Africa, 1987-2007.
BACKGROUND Childhood cancer is an emerging problem in Africa. Its extent is hazy because data are scarce, but it should be addressed. This is the first report from the South African Children's TumourExpand
A common Fanconi anemia mutation in black populations of sub-Saharan Africa.
Fanconi anemia (FA) is a genetically heterogeneous chromosomal instability syndrome associated with multiple congenital abnormalities, aplastic anemia, and cancer. We report that a deletion mutationExpand
An interinstitutional review of the value of FNAB in pediatric oncology in resource‐limited countries
Fine‐needle aspiration biopsy (FNAB) has been widely accepted as a reliable diagnostic modality in the general pediatric population, but its role in pediatric oncology still remains elusive. With newExpand
Hepatocellular carcinoma and liver tumors in South African children
The high regional incidence of hepatocellular carcinoma (HCC) in South Africa also may be present in children of the region, although the link to hepatitis B (HBV) appears less clear. The objectiveExpand
Malignancies in South African Children With HIV
Objectives: In 2008 the South African Children’s Cancer Study Group decided to review the epidemiology, management, and chemotherapy response of HIV-positive children with malignancy. Methods: ThisExpand
The Saint Siluan warning signs of cancer in children: Impact of education in rural South Africa
Two thirds of children with cancer never reach a specialist centre for treatment in South Africa. The majority of those who present have advanced disease. A campaign was undertaken to educate theExpand
Comparative study of Fanconi anemia in children of different ethnic origin in South Africa.
A comparative study of clinical, hematologic, and cytogenetic findings was made in 40 black and 35 white children with Fanconi anemia. The black children were Bantu-speaking Negroid stock of diverseExpand
Granulocytic sarcoma in children with acute myeloblastic leukemia and t(8;21).
BACKGROUND Granulocytic sarcomas (GS) have been associated with t(8;21). The prognosis of patients with GS is generally regarded as being less favorable than of patients with acute myeloblasticExpand