An enhanced MITOMAP with a global mtDNA mutational phylogeny
- E. Ruiz-Pesini, M. Lott, D. Wallace
- BiologyNucleic Acids Res.
- 18 December 2006
The MITOMAP () data system for the human mitochondrial genome has been greatly enhanced by the addition of a navigable mutational mitochondrial DNA (mtDNA) phylogenetic tree of ∼3000 mtDNA coding…
Effects of p21Waf1/Cip1/Sdi1 on cellular gene expression: implications for carcinogenesis, senescence, and age-related diseases.
- B. Chang, K. Watanabe, I. Roninson
- BiologyProceedings of the National Academy of Sciences…
- 11 April 2000
The results suggest that the effects of p21 induction on gene expression in senescent cells may contribute to the pathogenesis of cancer and age-related diseases.
p21Waf1/Cip1/Sdi1-induced growth arrest is associated with depletion of mitosis-control proteins and leads to abnormal mitosis and endoreduplication in recovering cells
- B. Chang, E. Broude, I. Roninson
- Biology, MedicineOncogene
- 20 April 2000
Induction of a cyclin-dependent kinase inhibitor p21Waf1/Cip1/Sdi1 is an integral part of cell growth arrest associated with senescence and damage response. p21 overexpression from an inducible…
Ancient mtDNA Genetic Variants Modulate mtDNA Transcription and Replication
- S. Suissa, Zhibo Wang, D. Mishmar
- BiologyPLoS Genetics
- 1 May 2009
The analysis demonstrates, for the first time, the functional impact of particular mtDNA haplogroup-defining control region mutations, paving the path towards assessing the functionality of both fixed and un-fixed genetic variants in the mitochondrial genome.
Mitochondrial DNA haplogroups influence AIDS progression
- Sher L. Hendrickson, H. Hutcheson, S. O’Brien
- Biology, MedicineAIDS (London)
- 30 November 2008
The associations found appear to support a functional explanation by which mitochondrial DNA variation among haplogroups, influencing ATP production, reactive oxygen species generation, and apoptosis, is correlated to AIDS disease progression; however, repeating these results in cohorts with different ethnic backgrounds would be informative.
Mitochondrial DNA Haplogroups Influence Lipoatrophy After Highly Active Antiretroviral Therapy
- Sher L. Hendrickson, L. Kingsley, S. O’Brien
- Biology, MedicineJournal of Acquired Immune Deficiency Syndromes
- 1 June 2009
The association between mitochondrial haplogroup and severity of lipoatrophy in HIV-infected European American patients on HAART in the Multicenter AIDS cohort Study found that mitochondrialhaplogroup H was strongly associated with increased atrophy.
Prospective Blinded Study of BRAFV600E Mutation Detection in Cell-Free DNA of Patients with Systemic Histiocytic Disorders
- D. Hyman, E. Diamond, O. Abdel-Wahab
- Medicine, Biology
- 6 December 2014
A prospective, blinded, multicenter study of BRAF V600E mutation detection in the cell-free DNA from plasma and urine of histiocytosis patients to determine the sensitivity/specificity of cfDNA mutation detection compared with tissue biopsy and to track disease burden serially with therapy revealed that the decline in mutant cfDNA burden in response to BRAF inhibitors was consistent with radiographic disease improvement.
Prospective blinded study of BRAFV600E mutation detection in cell-free DNA of patients with systemic histiocytic disorders.
- D. Hyman, E. Diamond, O. Abdel-Wahab
- Biology, MedicineCancer Discovery
- 2015
Results indicate that cfDNA BRAF(V600E) mutational analysis in plasma and urine provides a convenient and reliable method of detecting mutational status and can serve as a noninvasive biomarker to monitor response to therapy in LCH and ECD.
Effects of p 21 Waf 1 / Cip 1 / Sdi 1 on cellular gene expression : Implications for carcinogenesis , senescence , and age-related diseases
- B. Chang, Keiko Watanabe, I. Roninson
- Biology
- 2000
The results suggest that the effects of p21 induction on gene expression in senescent cells may contribute to the pathogenesis of cancer and age-related diseases.
Induction of Transcription by p21Waf1/Cip1/Sdi1: Role of NF?B and Effect of Non-steroidal Anti-inflammatory Drugs
- J. Poole, A. Thain, N. Perkins, I. Roninson
- BiologyCell Cycle
- 1 July 2004
p21 expression stimulates promoters of six p21-responsive human genes and the cytomegalovirus promoter, as well as an artificial promoter containing NF?B response elements, which suggest the feasibility of developing agents that decrease the effects of p21 on the responsive promoters and endogenous genes.
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