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Acetaminophen‐induced acute liver failure: Results of a United States multicenter, prospective study
In conclusion, acetaminophen hepatotoxicity far exceeds other causes of acute liver failure in the United States, and education of patients, physicians, and pharmacies to limit high‐risk use settings is recommended. Expand
AASLD position paper: The management of acute liver failure
This document has been designated as a Position Paper, since the topic contains more data based on expert opinion than on randomized controlled trials and is thus not considered to have the emphasis and certainty of a Practice Guideline. Expand
Infection and the progression of hepatic encephalopathy in acute liver failure.
This prospective evaluation points to infection and/or the resulting systemic inflammatory response as important factors contributing to worsening HE in ALF, mainly in patients with acetaminophen- induced ALF. Expand
Measurement of serum acetaminophen-protein adducts in patients with acute liver failure.
Measurement of serumacetaminophen-protein adducts reliably identified acetaminophen toxicity, and may be a useful diagnostic test for cases lacking historical data or other clinical information. Expand
Hepatotoxicity due to antibiotics.
- J. Polson
- Clinics in liver disease
- 1 August 2007
Diagnosis requires awareness of possible causal agents, vigilance in monitoring symptoms and sometimes biochemical tests, attention to careful history taking and establishing temporal association, and exclusion of competing etiologies. Expand
Assessment of prognosis in acute liver failure.
- J. Polson
- Seminars in liver disease
- 1 May 2008
Determining prognosis in acute liver failure (ALF) is vital to consideration of transplantation for these critically ill patients and considering etiology and coma grade prior to development of scores based on routine or specialized biomarkers may be important. Expand
Reemergence of hepatitis C virus after 8.5 years in a patient with hypogammaglobulinemia: evidence for an occult viral reservoir.
- William M. Lee, J. Polson, D. S. Carney, B. Sahin, M. Gale
- Biology, Medicine
- The Journal of infectious diseases
- 15 September 2005
The prolonged period of negativity for HCV RNA followed by relapse suggests that HCV may persist in apparent sustained viral responders, which is typical of patients with hypogammaglobulinemia. Expand
Clinical outcome and virological characteristics of hepatitis B‐related acute liver failure in the United States
HBV genotype D was more frequently found in patients with HBV‐ALF than those with chronic HBV infection in the US, and further studies are needed to determine if HBV genotypes play a role in the outcome of acuteHBV infection. Expand
False positive acetaminophen concentrations in patients with liver injury.
- J. Polson, F. Wians, +7 authors William M. Lee
- Clinica chimica acta; international journal of…
- 1 May 2008
False positive acetaminophen tests may result when enzymatic-colorimetric assays are used, most commonly with bilirubin concentrations >10 mg/dl, leading to potential clinical errors in this setting. Expand
Etiologies of acute liver failure: Location, location, location!
The characteristics and outcomes of 267 patients with ALF in Spain from 1992 to 2000 are described based on retrospective data obtained via questionnaires from 17 of Spain's 27 liver transplant centers, with major findings that hepatitis B was the most common cause, paracetamol was responsible for only a handful of cases, and nearly 1 of 3 were indeterminate. Expand