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Vesicle-associated membrane protein 3 (VAMP-3) and VAMP-8 are present in human platelets and are required for granule secretion.
TLDR
VAMP-3 and VAMP-8 form SNARE complexes with platelet syntaxin 4 and are required for platelet granule secretion, which is concluded to be related to platelet exocytosis. Expand
The Platelet Collagen Receptor Glycoprotein VI Is a Member of the Immunoglobulin Superfamily Closely Related to FcαR and the Natural Killer Receptors*
TLDR
The ability of the cloned GPVI cDNA to code for a functional platelet collagen receptor was demonstrated in the megakaryocytic cell line Dami, and it inhibited collagen-induced platelet aggregation. Expand
Molecular mechanisms of platelet exocytosis: insights into the "secrete" life of thrombocytes.
The critical role played by platelets in hemostasis, thrombosis, vascular remodeling, and healing is related to their function as exocytotic cells that secrete important effector molecules at theExpand
Platelet Activation and Signal Transduction by Convulxin, a C-type Lectin from Crotalus durissus terrificus (Tropical Rattlesnake) Venom via the p62/GPVI Collagen Receptor*
TLDR
Results suggest that convulxin uses the p62/GPVI but not the α2β1 part of the collagen signaling pathways to activate platelets, in contrast to other venom C-type lectins acting on platelets. Expand
The P‐selectin, tissue factor, coagulation triad
TLDR
The roles of P‐sel and TF‐positive MPs are discussed and strategies to modulate hemostasis by modulating the P‐sels, TF, coagulation triad are highlighted. Expand
Non-proteolytic activation of cellular protransglutaminase (placenta macrophage factor XIII).
TLDR
It was demonstrated that at high concentrations NaCl or KCl induced a non-proteolytic activation of cellular (placental macrophage) but not plasma protransglutaminase, which suggests that (one of) the physiological function(s) of the B subunit in plasma Factor XIII is to prevent the slow spontaneous activation of A subunit that would occur in a plasmatic environment. Expand
Phosphorylation of SNAP-23 in Activated Human Platelets*
TLDR
These studies show that SNAP-23 is phosphorylated in platelets during cell activation through a PKC-related mechanism at two or more sites with kinetics that parallel or precede granule secretion. Expand
Munc18-Syntaxin Complexes and Exocytosis in Human Platelets*
TLDR
In summary, Munc18 proteins bind to specific syntaxin isoforms in platelets despite the presence of other potential binding partners, suggesting that complex formation per se has a regulatory effect on triggered secretion. Expand
Comparison of body measurements of beef cows of different breeds
TLDR
Body measurements of 110 beef cows of 9 breeds were taken in December 2004 and correlations between age, live weight and measurements were evaluated and compared for the mentioned breeds. Expand
Protein Kinase C Phosphorylation of Syntaxin 4 in Thrombin-activated Human Platelets*
  • Sul-Hee Chung, J. Polgár, G. Reed
  • Chemistry, Medicine
  • The Journal of Biological Chemistry
  • 18 August 2000
TLDR
Evidence is provided that extracellular activation can be coupled through intracellular PKC signaling so as to modulate SNARE protein interactions involved in platelet exocytosis. Expand
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