J. Polak

Publications1,385
h-index134
Citations70,878
Highly Influential Citations1,283
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Third-Generation Biomedical Materials
TLDR
The next generation of biomaterials is combining these two properties, with the aim of developing materials that, once implanted, will help the body heal itself.
Human distribution and release of a putative new gut hormone, peptide YY.
The immunolocalization of protein gene product 9.5 using rabbit polyclonal and mouse monoclonal antibodies.
TLDR
Results demonstrate immunoreactive PGP 9.5 in neurons and nerve fibres at all levels of the central and peripheral nervous system, in many neuroendocrine cells, in part of the renal tubule, in spermatogonia and Leydig cells of the testis, and in ova and in some Cells of the pregnant and non-pregnant corpus luteum.
Colocalization of neuropeptide Y immunoreactivity in brainstem catecholaminergic neurons that project to the paraventricular nucleus of the hypothalamus
TLDR
The results suggest that NPY immunoreactivity is extensively co‐contained within adrenergic neurons of the C1, C2, and C3 groups that project to the PVH, while the correspondence in noradrenergic cell groups is less complete, and generally limited to a subset of neurons in the A1 cell group.
Neuropeptide Y distribution in the rat brain.
TLDR
Column chromatography of brain extracts and double immunostaining experiments indicate that neuropeptide Y is the endogenous brain peptide responsible for Immunostaining of pancreatic polypeptides-like immunoreactivity in the mammalian brain.
Expression of angiogenesis‐related molecules in plexiform lesions in severe pulmonary hypertension: evidence for a process of disordered angiogenesis
TLDR
It is postulated that in lungs with SPH, endothelial cells in plexiform lesions express genes encoding for proteins involved in angiogenesis, in particular, vascular endothelial growth factor (VEGF) and those involved in VEGF receptor‐2 (VEGFR‐2) signalling.
Differentiation of osteoblasts and in vitro bone formation from murine embryonic stem cells.
TLDR
The application of a quantitative assay for the derivation of osteoblast lineage progenitors from pluripotent ES cells is demonstrated, which could be applied to obtain purified osteoblasts to analyze mechanisms of osteogenesis and for use of ES cells in skeletal tissue repair.
Development of neuroendocrine tumors in the gastrointestinal tract of transgenic mice. Heterogeneity of hormone expression.
TLDR
Data indicate that neuroendocrine tumors arise both in beta cell and S-cell subpopulations of transgenic mice carrying insulin-promoted oncogenes and in some secretin-immunoreactive cells of small intestinal mucosa.
Spectroscopic study of human lung epithelial cells (A549) in culture: living cells versus dead cells.
TLDR
The capability of Raman spectroscopy for use as a noninvasive method to distinguish cells at different stages of the cell cycle and living cells from dead cells is shown.
Localization of nitric oxide synthase in the adult rat brain.
The distribution of the immunoreactivity to nitric oxide synthase has been examined from rostral to caudal areas of the rat central nervous system using light microscopy. Endogenous nitric oxide…
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