• Publications
  • Influence
Preferential recruitment of interferon‐γ–expressing TH17 cells in multiple sclerosis
There is substantial evidence supporting the role of interferon (IFN)‐γ–producing T helper (TH) 1 and interleukin (IL)‐17–expressing TH17 lymphocytes in multiple sclerosis (MS) and its animal model,Expand
  • 397
  • 22
Pronounced impact of Th1/E47cs mutation compared with -491 AT mutation on neural APOE gene expression and risk of developing Alzheimer's disease.
Possession of the apolipoprotein E (APOE) epsilon4 allele is the most frequently associated genetic susceptibility factor for Alzheimer's disease (AD). Recently, new polymorphisms in the regulatoryExpand
  • 142
  • 14
Glioblastomas with an Oligodendroglial Component: A Pathological and Molecular Study
Glioblastoma (GBM) is considered by the WHO classification to represent the most malignant grade of the astrocytic tumors. However, a subset of GBM includes recognizable areas with oligodendroglialExpand
  • 139
  • 10
  • PDF
Migration of multiple sclerosis lymphocytes through brain endothelium.
CONTEXT T-lymphocyte migration through the blood-brain barrier is a central event in the process of lesion formation in multiple sclerosis (MS). OBJECTIVES To assess the ability of lymphocytesExpand
  • 116
  • 8
  • PDF
Molecular heterogeneity of oligodendrogliomas suggests alternative pathways in tumor progression
Objective: To identify different genetic molecular profiles in oligodendrogliomas and to evaluate their prognostic significance. Methods: The main genetic alterations reported in glial tumors wereExpand
  • 119
  • 5
Melanoma cell adhesion molecule identifies encephalitogenic T lymphocytes and promotes their recruitment to the central nervous system.
In multiple sclerosis, encephalitogenic CD4(+) lymphocytes require adhesion molecules to accumulate into central nervous system inflammatory lesions. Using proteomic techniques, we identifiedExpand
  • 91
  • 4
Location score and haplotype analyses of the locus for autosomal recessive spastic ataxia of Charlevoix-Saguenay, in chromosome region 13q11.
Autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS) is a clinically homogeneous form of early-onset familial spastic ataxia with prominent myelinated retinal nerve fibers. More thanExpand
  • 81
  • 4
Bradykinin B1 receptor expression and function on T lymphocytes in active multiple sclerosis
Background: Lesion development in MS is initiated by migration of inflammatory cells into the central nervous system, a process dependent on endothelial cell–lymphocyte interaction. Bradykinin B1Expand
  • 59
  • 2
Effect of apolipoprotein E deficiency on reactive sprouting in the dentate gyrus of the hippocampus following entorhinal cortex lesion: role of the astroglial response
This study investigated the effect of apolipoporotein E (apoE) deficiency on hippocampal reactive sprouting responses of the septohippocampal cholinergic (SHC) and commissural/associational fibersExpand
  • 34
  • 2
A comprehensive model of care for rehabilitation of children with acquired brain injuries.
BACKGROUND Acquired brain injury (ABI) is a leading cause of death and lifelong acquired disability in children and remains a significant public health issue. Deficits may only become fully apparentExpand
  • 65
  • 2