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Olfactory receptor responding to gut microbiota-derived signals plays a role in renin secretion and blood pressure regulation
Olfactory receptors are G protein-coupled receptors that mediate olfactory chemosensation and serve as chemosensors in other tissues. We find that Olfr78, an olfactory receptor expressed in theExpand
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Functional expression of the olfactory signaling system in the kidney
Olfactory-like chemosensory signaling occurs outside of the olfactory epithelium. We find that major components of olfaction, including olfactory receptors (ORs), olfactory-related adenylate cyclaseExpand
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Polycystin-1 C-terminal tail associates with beta-catenin and inhibits canonical Wnt signaling.
Polycystin-1 (PC1), the product of the PKD1 gene mutated in the majority of autosomal dominant polycystic kidney disease (ADPKD) cases, undergoes a cleavage resulting in the intracellular release ofExpand
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BK-{beta}1 subunit: immunolocalization in the mammalian connecting tubule and its role in the kaliuretic response to volume expansion.
Large, Ca(2+)-activated K(+) channels (BK), comprised of alpha- and beta-subunits, mediate K(+) secretion during high flow rates in distal nephron segments. Because the BK-beta1 subunit enhancesExpand
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A Cleavable N-Terminal Signal Peptide Promotes Widespread Olfactory Receptor Surface Expression in HEK293T Cells
Olfactory receptors (ORs) are G protein-coupled receptors that detect odorants in the olfactory epithelium, and comprise the largest gene family in the genome. Identification of OR ligands typicallyExpand
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A novel SCFA receptor, the microbiota, and blood pressure regulation
The maintenance of blood pressure homeostasis is a complex process which is carefully regulated by a variety of inputs. We recently identified two sensory receptors (Olfactory receptor 78 and GExpand
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BK channels in the kidney: role in K(+) secretion and localization of molecular components.
  • J. Pluznick, S. Sansom
  • Medicine, Chemistry
  • American journal of physiology. Renal physiology
  • 1 September 2006
Although it is generally accepted that ROMK is the K(+) secretory channel in the mammalian distal nephron, recent in vitro and in vivo studies have provided evidence that large-conductanceExpand
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Renal fluid and electrolyte handling in BKCa-β1−/− mice
Large-conductance Ca2+-activated K+ channels (BKCa) are composed of pore-forming α-subunits and one of four accessory β-subunits. The β1-subunit, found predominantly in smooth muscle, modulates the...
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An Olfactory Cilia Pattern in the Mammalian Nose Ensures High Sensitivity to Odors
In many sensory organs, specialized receptors are strategically arranged to enhance detection sensitivity and acuity. It is unclear whether the olfactory system utilizes a similar organizationalExpand
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Renal and cardiovascular sensory receptors and blood pressure regulation.
  • J. Pluznick
  • Biology, Medicine
  • American journal of physiology. Renal physiology
  • 15 August 2013
Studies over the past decade have highlighted important roles played by sensory receptors outside of traditionally sensory tissues; for example, taste receptors participate in pH sensing in theExpand
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