J. Plenkiewicz

Publications75
h-index11
Citations462
Highly Influential Citations6
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Synthesis of 4-deoxy analogues of 2-acetamido-2-deoxy-D-glucose and 2-acetamido-2-deoxy-D-xylose and their effects on glycoconjugate biosynthesis.
4-Deoxy analogues of 2-acetamido-2-deoxy-D-glucose and 2-acetamido-2-deoxy-D-xylose were synthesized and evaluated as inhibitors of glycoconjugate biosynthesis. Methyl… Expand
Synthesis of new chiral ionic liquids from α-hydroxycarboxylic acids
New functionalized optically active N-methylimidazolium ionic liquids with an asymmetric center at the β-position to the imdazole ring were synthesized as bromide salts from optically active… Expand
Enantioselective reduction of α,β-unsaturated ketones by Geotrichum candidum, Mortierella isabellina and Rhodotorula rubra yeast
Abstract The reduction of 3-methyl-4-phenyl-3-buten-2-one and its phenyl-substituted derivatives by microorganisms was investigated. Growing cells of Mortierella isabellina DSM1414 and Geotrichum… Expand
Chemoenzymatic synthesis and biological evaluation of enantiomerically enriched 1-(β-hydroxypropyl)imidazolium- and triazolium-based ionic liquids
TLDR
Racemic 1-(β-hydroxypropyl)azoles were prepared by solvent-free direct regioselective ring opening of 1,2-propylene oxide with imidazole or 1,1,2,4-triazole and tested against a wide range of microorganisms. Expand
Preparation and thermal stability of optically active 1,2,4-triazolium-based ionic liquids
The synthesis of optically active ionic liquids, in a four-step reaction sequence, is described. In the first step an oxirane ring of cyclohexene oxide was opened with 1,2,4-triazole, yielding a… Expand
Optically Active Nitrile Oxides: Synthesis and 1,3‐Dipolar Cycloaddition Reactions.
Influence of monosaccharide derivatives on liver cell glycosaminoglycan synthesis: 3-deoxy-D-xylo-hexose (3-deoxy-D-galactose) and methyl (methyl 4-chloro-4-deoxy-beta-D-galactopyranosid) uronate.
TLDR
Results show that part of the effect of compound 10 on GAG synthesis is not mediated by an inhibition of proteoglycan core protein synthesis, and potential metabolic routes for each analogue's effect are presented. Expand
Synthesis and Antimicrobial Activity of Imidazolium and Triazolium Chiral Ionic Liquids
A simple and efficient procedure for the synthesis of new optically active imidazolium and triazolium ionic liquids in a three step reaction sequence is described. In the first step, the ring opening… Expand
Bicyclic [b]-heteroannulated pyridazine derivatives--II. Structure-activity relationships in the 6-aryltriazolo-[4,3-b]pyridazine ligands of the benzodiazepine receptor.
TLDR
Electronic parameters (molecular electrostatic potential MEP, charge distribution on the nitrogen atoms, dipole moment mu and ionization potential IP) and a model of the triazolopyridazine-benzodiazepine receptor interaction was proposed, which revealed a significant dependence on IP. Expand
Effects of 4-deoxy-L-threo-pentose, a novel carbohydrate, on neural cell proteoglycan synthesis and function.
TLDR
The data suggest that 4-deoxyxylose inhibits neurite outgrowth by altering the sulphation of the GAGs of heparan sulphate proteoglycans, a novel carbohydrate synthesized by way of reductive dechlorination of a chlorodeoxy sugar. Expand
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