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Effects of extracellular pH on agonism and antagonism at a recombinant P2X2 receptor
Under voltage‐clamp conditions, the activity of agonists and antagonists at a recombinant P2X2 receptor expressed in Xenopus oocytes was examined at different levels of extracellular pH (pHe). InExpand
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Full sensitivity of P2times2 purinoceptor to ATP revealed by changing extracellular pH
A full pharmacological characterization was carried out on a recombinant ATP‐gated ion channel (P2times2 purinoceptor) expressed in Xenopus oocytes. This slowly‐desensitizing neuronal P2times2Expand
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Diinosine pentaphosphate (IP5I) is a potent antagonist at recombinant rat P2X1 receptors
The antagonist activity of a series of diinosine polyphosphates (IpnI, where n=3, 4, 5) was assessed against ATP‐activated inward currents at rat P2X1–4 receptors expressed in Xenopus oocytes andExpand
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A novel P1 purinoceptor activates an outward K+ current in follicular oocytes of Xenopus laevis.
Follicular oocytes of Xenopus laevis possess P1 purinoceptors where, seemingly, both adenosine (Ado) and ATP are agonists. The basis of ATP agonism at this P1 purinoceptor was investigated usingExpand
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The activation of P1‐ and P2‐purinoceptors in the guinea‐pig left atrium by diadenosine polyphosphates
1 The effects of P1, P2‐di(adenosine) pyrophosphate (AP2A), P1, P3‐di(adenosine) triphosphate (AP3A), P1, P4‐di(adenosine) tetraphosphate (AP4A), P1, P5‐di(adenosine) pentaphosphate (AP5A), ATP, α,Expand
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Effects of P2-purinoceptor antagonists on degradation of adenine nucleotides by ecto-nucleotidases in folliculated oocytes of Xenopus laevis.
The aim of the present study was to examine the effects of a number of P2-purinoceptor antagonists on degradation of adenine nucleotides by Xenopus laevis oocyte ecto-nucleotidase. FolliculatedExpand
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Characterization of Nucleotide Transport into Rat Brain Synaptic Vesicles
Abstract : ATP transport to synaptic vesicles from rat brain has been studied using the fluorescent substrate analogue 1,N6‐ethenoadenosine 5′‐triphosphate (ε‐ATP), The increase in intravesicularExpand
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Modulation of the rat hippocampal dinucleotide receptor by adenosine receptor activation.
Diadenosine pentaphosphate (Ap(5)A) and ATP stimulate an intracellular free calcium concentration ([Ca(2+)](I)) increase in rat hippocampal synaptosomes via different receptors as demonstrated by theExpand
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2-MeS-beta,gamma-CCl2-ATP is a potent agent for reducing intraocular pressure.
Extracellular nucleotides can modify the production or drainage of the aqueous humor via activation of P2 receptors and therefore affect the intraocular pressure (IOP). We have synthesized slowlyExpand
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Interaction between Dinucleotide and Nicotinic Receptors in Individual Cholinergic Terminals
Functional ionotropic nucleotidic receptors responding to diadenosine pentaphospate and nicotinic receptors responding to epibatidine coexpress in 19% of the total rat midbrain cholinergic terminals,Expand
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