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Old Iron, Young Copper: from Mars to Venus
It is concluded that the early chemistry of life used water soluble ferrous iron while copper was in the water-insoluble Cu(I) state as highly insoluble sulphides, and copper, now bioavailable, was ideally suited to exploit the oxidizing power of dioxygen. Expand
Iron and activated oxygen species in biology: The basic chemistry
A critical review concerning the chemical reactions involved when superoxide or hydrogen peroxide meet iron complexes is presented. Expand
Chemistry for an essential biological process: the reduction of ferric iron
In a short overview of iron chemistry, some of the pitfalls using standard redox potentials are pointed out, the interaction of ferric complexes with hydrogen peroxide to give hydroxyl radicals are commented on, and the role of dissimilatory ferric reduction in microbial respiration and biomineralization is discussed. Expand
Ferric reductases or flavin reductases?
The common structural and catalytic properties of these enzymes are described and shown to be identical to those of flavin reductases, which strongly suggests that, in general, the reduction of iron depends on reduced flavins provided by flavin reducing enzymes. Expand
Calcein as a Fluorescent Probe for Ferric Iron
- F. Thomas, G. Serratrice, +4 authors J. Laulhère
- Chemistry, Medicine
- The Journal of Biological Chemistry
- 7 May 1999
CA is a good chemosensor for iron(III) in cells and biological fluids, but not for Fe(II), and the interest of quantifying iron buffers in biochemical studies of iron, in vitro as well as in cells is discussed. Expand
Iron and citric acid: A fuzzy chemistry of ubiquitous biological relevance
A review concerning the species which can arise when iron salts and citric acid are mixed together and the data commented on are required for a correct interpretation of the chemical processes. Expand
Iron mobilisation and cellular protection by a new synthetic chelator O-Trensox.
The protective effect of O-Trensox against iron toxicity induced in hepatocyte cultures by ferric citrate was shown by decreased release of the enzymes lactate dehydrogenase, aspartate isinotransferase, and alanine aminotranferase from the cultures and, using electron paramagnetic resonance (EPR) measurements, decreased production of lipid radicals. Expand
Iron: metabolism, toxicity and therapy.
This paper is an overview on iron metabolism, iron toxicity and therapeutics against this toxicity. The attention has been focused on: i) the solubilization of iron by living organisms; ii) the iron… Expand
New trends in the chemistry of iron(III) citrate complexes: correlations between X-ray structures and solution species probed by electrospray mass spectrometry and kinetics of iron uptake from…
Kinetic studies of iron uptake from citrate species by iron chelators confirmed the results indicated by the ESI-MS studies, and allowed the relative molar fraction of mononuclear versus polynuclear complexes to be determined, which depends on the Fe:cit molar ratio. Expand
The new orally active iron chelator ICL670A exhibits a higher antiproliferative effect in human hepatocyte cultures than O-trensox.
- K. Chantrel-Groussard, F. Gaboriau, +5 authors G. Lescoat
- Biology, Medicine
- European journal of pharmacology
- 17 July 2006
It is suggested that ICL670A has the most efficient antitumoral effect, blocks cell proliferation by a pathway different of O-trensox and may constitute a potential drug for anticancer therapy. Expand