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Cytochrome P450 2C9 polymorphisms: a comprehensive review of the in-vitro and human data.
TLDR
Clinical investigations evaluating the metabolic consequences in individuals expressing the CYP2C9*2, *3, *4, *5, or *6 alleles are required before large-scale clinical genotyping can be recommended.
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Clinical Pharmacokinetics of Fluvastatin
TLDR
Fluvastatin is relatively hydrophilic, compared with the semisynthetic HMG-CoA reductase inhibitors, and, therefore, it is extensively absorbed from the gastrointestinal tract, and does not appear to have a significant effect on other CYP isoenzymes or P-glycoprotein-mediated transport in vivo.
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Tolbutamide, Flurbiprofen, and Losartan as Probes of CYP2C9 Activity in Humans
TLDR
Tlbutamide is a better CYP2C9 probe than flurbiprofen and losartan, and the 0‐ to 12‐hour amount of 4'‐hydroxytolbutamide and carboxytol butamide is the best urinary measure of its metabolism.
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Altered protein binding of etoposide in patients with cancer
TLDR
This study corroborates previous reports of etoposide PB in normal human serum and demonstrates altered PB in patients with abnormal serum albumin or bilirubin levels.
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Losartan and E3174 Pharmacokinetics in Cytochrome P450 2C9*1/*1, *1/*2, and *1/*3 Individuals
Study Objective. To determine if differences in the pharmacokinetics of losartan and its pharmacologically active E3174 metabolite exist among individuals expressing the cytochrome P450 (CYP)…
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Effect of Fluoxetine on Carvedilol Pharmacokinetics, CYP2D6 Activity, and Autonomic Balance in Heart Failure Patients
TLDR
Fluoxetine administration resulted in a stereospecific inhibition of carvedilol metabolism, with the R(+) enantiomer increasing to a greater extent than the S(−) enantiomers, however, this interaction was of little clinical significance in the authors' sample population.
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Effects of erythromycin or rifampin on losartan pharmacokinetics in healthy volunteers
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Overview of niacin formulations: differences in pharmacokinetics, efficacy, and safety.
  • J. Pieper
  • Medicine
    American journal of health-system pharmacy : AJHP…
  • 1 July 2003
TLDR
The ER niacin formulation, with an intermediate dissolution rate between the dissolution rates of IR and SR niacIn, demonstrates reduced rates of cutaneous flushing compared with IR niac in and hepatotoxic effects compared with SR niakin.
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Understanding niacin formulations.
  • J. Pieper
  • Medicine
    The American journal of managed care
  • 1 September 2002
TLDR
The pharmacist should be familiar with the differences among and the advantages and disadvantages of each formulation to educate patients and help them achieve the optimal therapeutic benefit of niacin while minimizing adverse effects.
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Effects of chronic phenobarbital on verapamil disposition in humans.
TLDR
The pharmacokinetic theories derived for hepatic extraction of drugs subject to a high metabolic clearance can be successfully applied to men after liver enzyme induction with phenobarbital.
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