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NRMT is an α-N-methyltransferase that methylates RCC1 and Retinoblastoma Protein
The post-translational methylation of α-amino groups was first discovered over 30 years ago on the bacterial ribosomal proteins L16 and L33 (refs 1, 2), but almost nothing is known about the function…
Posttranslational modification of CENP-A influences the conformation of centromeric chromatin
- A. Bailey, T. Panchenko, +9 authors D. Foltz
- Biology, MedicineProceedings of the National Academy of Sciences
- 1 July 2013
Three posttranslational modifications on human CENP-A N termini using high-resolution MS are reported: trimethylation of Gly1, phosphorylation of Ser16 and Ser18 and phosphorylated of Serine 16 and 18, which are important for chromosome segregation during mitosis.
Phosphine gas in the cloud decks of Venus
Measurements of trace gases in planetary atmospheres help us explore chemical conditions different to those on Earth. Our nearest neighbour, Venus, has cloud decks that are temperate but hyperacidic.…
NRMT2 is an N-terminal monomethylase that primes for its homologue NRMT1.
- J. Petkowski, Lindsay A. Bonsignore, +4 authors Christine E. Schaner Tooley
- Biology, MedicineThe Biochemical journal
- 15 December 2013
It is proposed that NRMT2 activates NRMT1 by priming its substrates for trimethylation, and it is shown for the first time thatNRMT2 also has N-terminal methylation activity and recognizes the same N-Terminal consensus sequences as NRMT (now NRMT 1).
The Venusian Lower Atmosphere Haze as a Depot for Desiccated Microbial Life: A Proposed Life Cycle for Persistence of the Venusian Aerial Biosphere.
- S. Seager, J. Petkowski, +4 authors J. Greaves
- Environmental Science, PhysicsAstrobiology
- 13 August 2020
It is proposed for the first time that the only way life can survive indefinitely is with a life cycle that involves microbial life drying out as liquid droplets evaporate during settling, with the small desiccated "spores" halting at, and partially populating, the Venus atmosphere stagnant lower haze layer.
Toward a List of Molecules as Potential Biosignature Gases for the Search for Life on Exoplanets and Applications to Terrestrial Biochemistry.
A new approach to the subject of biosignature gases is presented by systematically constructing lists of volatile molecules in different categories, and it is shown that about one-fourth of CNOPSH molecules are known to be produced by life on Earth.
Substrate specificity of mammalian N-terminal α-amino methyltransferase NRMT.
- J. Petkowski, Christine E. Schaner Tooley, +6 authors I. Macara
- Biology, MedicineBiochemistry
- 31 July 2012
In vitro peptide methylation assays and substrate immunoprecipitations are used to show that the canonical M-X-P-K methylation motif is not the only one recognized by NRMT, and it is predicted that N-terminal methylation is a widespread post-translational modification and that there is interplay between N- terminal acetylation and N- terminal methylation.
Crystal structures of TM0549 and NE1324—two orthologs of E. coli AHAS isozyme III small regulatory subunit
- J. Petkowski, M. Chruszcz, +8 authors W. Minor
- Biology, MedicineProtein science : a publication of the Protein…
- 1 July 2007
Crystal structures of two orthologs of the regulatory subunit of acetohydroxyacid synthase III (AHAS, EC 184.108.40.206) from Thermotoga maritima (TM0549) and Nitrosomonas europea (NE1324) were determined…
Structure of Escherichia coli RutC, a member of the YjgF family and putative aminoacrylate peracid reductase of the rut operon.
- A. Knapik, J. Petkowski, +5 authors W. Minor
- Biology, MedicineActa crystallographica. Section F, Structural…
- 1 November 2012
The final model revealed that this protein has a Bacillus chorismate mutase-like fold and forms a homotrimer with a hydrophobic cavity in the center of the structure and ligand-binding clefts between two subunits.
Phosphine on Venus Cannot Be Explained by Conventional Processes.
This work thoroughly explores the potential pathways of formation of phosphine in a venusian environment, including in the planet's atmosphere, cloud and haze layers, surface, and subsurface, and provides a template for investigation of phosphines as a biosignature on other worlds.