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Anchors aweigh: protein localization and transport mediated by transmembrane domains
The transmembrane domains (TMDs) of integral membrane proteins have emerged as major determinants of intracellular localization and transport in the secretory and endocytic pathways. UnlikeExpand
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Pseudomonas aeruginosa virulence genes identified in a Dictyostelium host model
The human pathogen Pseudomonas aeruginosa has been shown previously to use similar virulence factors when infecting mammalian hosts or Dictyostelium amoebae. Here we randomly mutagenized a clinicalExpand
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TM9SF4 is required for Drosophila cellular immunity via cell adhesion and phagocytosis
Nonaspanins are characterised by a large N-terminal extracellular domain and nine putative transmembrane domains. This evolutionarily conserved family comprises three members in DictyosteliumExpand
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Rac2 is a major actor of Drosophila resistance to Pseudomonas aeruginosa acting in phagocytic cells
Pathogen recognition and engulfment by phagocytic cells of the blood cell lineage constitute the first line of defense against invading pathogens. This cellular immune response is conservedExpand
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TM9/Phg1 and SadA proteins control surface expression and stability of SibA adhesion molecules in Dictyostelium
ETOC: TM9/Phg1 proteins are essential for cellular adhesion in many systems, from Dictyostelium to human cells, yet their exact role remains unknown. We demonstrate that TM9 proteins participate inExpand
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Cloning and expression of a cohemolysin, the CAMP factor of Actinobacillus pleuropneumoniae.
The genetic determinant of the cohemolysin which is responsible for the CAMP phenomenon, a cohemolysis, of Actinobacillus pleuropneumoniae was cloned in Escherichia coli. Total DNA from the A.Expand
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Vps13F links bacterial recognition and intracellular killing in Dictyostelium
Bacterial sensing, ingestion, and killing by phagocytic cells are essential processes to protect the human body from infectious microorganisms. The cellular mechanisms involved in intracellularExpand
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TM9 family proteins control surface targeting of glycine-rich transmembrane domains
ABSTRACT TM9 family proteins (also named Phg1 proteins) have been previously shown to control cell adhesion by determining the cell surface localization of adhesion proteins such as the DictyosteliumExpand
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Weevil pgrp-lb prevents endosymbiont TCT dissemination and chronic host systemic immune activation
Significance Permanent infections with beneficial bacteria are widespread in nature and are believed to play a pivotal role in evolution. How hosts’ immune functions are regulated to maintainExpand
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