Author pages are created from data sourced from our academic publisher partnerships and public sources.
The importance of endothelin-1 for vascular dysfunction in cardiovascular disease.
Endothelin (ET)-1 is a potent vasoconstrictor peptide originally isolated from endothelial cells. Its production is stimulated in a variety of different cell types under the influence of risk factors… Expand
Arginase as a potential target in the treatment of cardiovascular disease: reversal of arginine steal?
Functional integrity of the vascular endothelium is of fundamental importance for normal vascular function. A key factor regulating endothelial function is the bioavailability of nitric oxide (NO).… Expand
Glucagon-like peptide-1 relaxes rat conduit arteries via an endothelium-independent mechanism
A lot of interest has engendered in glucagon-like peptide-1 (GLP-1) as an emerging new drug in the treatment of type 2 diabetes. GLP-1 exerts several effects that reduce glycemia in type 2 diabetes… Expand
Myocardial infarction mediated by endothelin receptor signaling in hypercholesterolemic mice.
- G. Caligiuri, Bernard Henri Lévy, J. Pernow, P. Thorén, G. Hansson
- Proceedings of the National Academy of Sciences…
- 8 June 1999
Myocardial infarction is linked to atherosclerosis, yet the sequence leading from silent coronary atherosclerosis to acute myocardial infarction has remained unclear. Here we show that… Expand
Arginase inhibition mediates cardioprotection during ischaemia-reperfusion.
AIMS Nitric oxide (NO) is vital for the integrity of the cardiovascular system and protection against ischaemic heart disease. Arginase is up-regulated during ischaemia-reperfusion (IR) and this… Expand
PPAR-alpha activation protects the type 2 diabetic myocardium against ischemia-reperfusion injury: involvement of the PI3-Kinase/Akt and NO pathway.
- A. Bulhak, C. Jung, Claes-Göran Ostenson, J. Lundberg, Per-Ove Sjöquist, J. Pernow
- American journal of physiology. Heart and…
- 1 March 2009
Several clinical studies have shown the beneficial cardiovascular effects of fibrates in patients with diabetes and insulin resistance. The ligands of peroxisome proliferator-activated receptor-alpha… Expand
New perspectives on endothelin-1 in atherosclerosis and diabetes mellitus.
Endothelin-1 (ET-1) is a vasoconstrictor, proinflammatory and proliferative endothelial cell-derived peptide that is of significant importance in the regulation of vascular function. It is involved… Expand
Neuropeptide Y: presence in perivascular noradrenergic neurons and vasoconstrictor effects on skeletal muscle blood vessels in experimental animals and man
- J. Pernow, A. Öhlén, T. Hökfelt, O. Nilsson, J. Lundberg
- Biology, Medicine
- Regulatory Peptides
- 1 December 1987
The presence of neuropeptide Y (NPY)-like immunoreactivity (-LI) in sympathetic perivascular nerves and the functional effects of NPY and noradrenaline (NA) on vascular tone were studied in skeletal… Expand
Urotensin II evokes potent vasoconstriction in humans in vivo
The peptide urotensin II (U II) evokes potent vasoconstriction in non‐human primates. In human blood vessels studied in vitro variable effects of U II are reported; vasoconstriction, vasodilatation… Expand
Arginase Inhibition Improves Endothelial Function in Patients With Coronary Artery Disease and Type 2 Diabetes Mellitus
Background— Endothelial dysfunction plays an important role in the early development of atherosclerosis and vascular complications in type 2 diabetes mellitus. Increased expression and activity of… Expand