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The importance of endothelin-1 for vascular dysfunction in cardiovascular disease.
Endothelin (ET)-1 is a potent vasoconstrictor peptide originally isolated from endothelial cells. Its production is stimulated in a variety of different cell types under the influence of risk factorsExpand
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Arginase as a potential target in the treatment of cardiovascular disease: reversal of arginine steal?
Functional integrity of the vascular endothelium is of fundamental importance for normal vascular function. A key factor regulating endothelial function is the bioavailability of nitric oxide (NO).Expand
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Glucagon-like peptide-1 relaxes rat conduit arteries via an endothelium-independent mechanism
A lot of interest has engendered in glucagon-like peptide-1 (GLP-1) as an emerging new drug in the treatment of type 2 diabetes. GLP-1 exerts several effects that reduce glycemia in type 2 diabetesExpand
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Myocardial infarction mediated by endothelin receptor signaling in hypercholesterolemic mice.
Myocardial infarction is linked to atherosclerosis, yet the sequence leading from silent coronary atherosclerosis to acute myocardial infarction has remained unclear. Here we show thatExpand
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Arginase inhibition mediates cardioprotection during ischaemia-reperfusion.
AIMS Nitric oxide (NO) is vital for the integrity of the cardiovascular system and protection against ischaemic heart disease. Arginase is up-regulated during ischaemia-reperfusion (IR) and thisExpand
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PPAR-alpha activation protects the type 2 diabetic myocardium against ischemia-reperfusion injury: involvement of the PI3-Kinase/Akt and NO pathway.
Several clinical studies have shown the beneficial cardiovascular effects of fibrates in patients with diabetes and insulin resistance. The ligands of peroxisome proliferator-activated receptor-alphaExpand
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New perspectives on endothelin-1 in atherosclerosis and diabetes mellitus.
Endothelin-1 (ET-1) is a vasoconstrictor, proinflammatory and proliferative endothelial cell-derived peptide that is of significant importance in the regulation of vascular function. It is involvedExpand
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Neuropeptide Y: presence in perivascular noradrenergic neurons and vasoconstrictor effects on skeletal muscle blood vessels in experimental animals and man
The presence of neuropeptide Y (NPY)-like immunoreactivity (-LI) in sympathetic perivascular nerves and the functional effects of NPY and noradrenaline (NA) on vascular tone were studied in skeletalExpand
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Urotensin II evokes potent vasoconstriction in humans in vivo
The peptide urotensin II (U II) evokes potent vasoconstriction in non‐human primates. In human blood vessels studied in vitro variable effects of U II are reported; vasoconstriction, vasodilatationExpand
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Arginase Inhibition Improves Endothelial Function in Patients With Coronary Artery Disease and Type 2 Diabetes Mellitus
Background— Endothelial dysfunction plays an important role in the early development of atherosclerosis and vascular complications in type 2 diabetes mellitus. Increased expression and activity ofExpand
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