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Comparison of effects of desipramine and amitriptyline on EEG sleep of depressed patients
Despite their widespread use, there are few data concerning the effects of tricyclic antidepressants on EEG sleep in depression. The present study documented the effects of desipramine (DMI, n=17)Expand
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S-mephenytoin 4-hydroxylation in older Americans
SummaryTo examine whether a drug-metabolizing enzyme changes with normal aging, the S:R index of S-mephenytoin 4-hydroxylation was determined in 150, unmedicated elderly Americans (mean age 75.4).TenExpand
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Pharmacologic evidence to support clinical decision making for peripartum methadone treatment
RationaleLimited pharmacological data are available to guide methadone treatment during pregnancy and postpartum.ObjectivesStudy goals were to (1) characterize changes in methadone dose acrossExpand
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The Electrocardiographic and Antiarrhythmic Effects of Imipramine Hydrochloride at Therapeutic Plasma Concentrations
The electrocardiographic effects of imipramine hydrochloride at therapeutic plasma concentrations were determined in 44 depressed patients during a 6-week clinical outcome study of depression. DuringExpand
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Methylphenidate Interaction With Both Anticonvulsants and Ethyl Biscoumacetate
Therapeutic doses of methylphenidate hydrochloride, given for the minimal cerebral dysfunction syndrome, were found to raise the serum levels of primidone, diphenylhydantoin sodium, and phenobarbitalExpand
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Metabolism and Measurement of Chloroprocaine, an Ester-Type Local Anesthetic
Abstract Blood levels of intact chloroprocaine were determined using a GLC procedure capable of detecting as little as 10 ng of chloroprocaine/ml of blood. It was necessary to deactivate plasmaExpand
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The effect of the interaction of pyrazinamide and probenecid on urinary uric acid excretion in man.
Complex interactions occur between pyrazinamide (PZA) and probenecid in man involving both the metabolism and distribution of the drugs, and their effects on renal tubules. Pretreatment with PZAExpand
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Studies of interactions among drugs in man at the renal level: Probenecid and sulfinpyrazone
The interactions between the uricosuric agents probenecid and sulfinpyrazone were studied in subjects with gout by means of renal clearance experiments. It was found that in both acid and alkalineExpand
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Observations on the disposition of probenecid in patients receiving allopurinol.
The effect of allopurinol on the metabolism of pro benecid was evaluated in patients for two reasons: allopurinol was re ported to inhibit drug metabolism, and combined therapy (allopurinol andExpand
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