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A Core Complex of BBS Proteins Cooperates with the GTPase Rab8 to Promote Ciliary Membrane Biogenesis
Primary cilium dysfunction underlies the pathogenesis of Bardet-Biedl syndrome (BBS), a genetic disorder whose symptoms include obesity, retinal degeneration, and nephropathy. However, despite theExpand
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A molecular network for de novo generation of the apical surface and lumen
To form epithelial organs cells must polarize and generate de novo an apical domain and lumen. Epithelial polarization is regulated by polarity complexes that are hypothesized to direct downstreamExpand
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Novel neurotrophic factor CDNF protects and rescues midbrain dopamine neurons in vivo
In Parkinson’s disease, brain dopamine neurons degenerate most prominently in the substantia nigra. Neurotrophic factors promote survival, differentiation and maintenance of neurons in developing andExpand
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Coordination of Rab8 and Rab11 in primary ciliogenesis
Primary cilia are microtubule-based membrane projections located at the surface of many cells. Defects in primary cilia formation have been implicated in a number of genetic disorders, such asExpand
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AS160, the Akt substrate regulating GLUT4 translocation, has a functional Rab GTPase-activating protein domain.
Recently, we described a 160 kDa protein (designated AS160, for Akt substrate of 160 kDa) with a predicted Rab GAP (GTPase-activating protein) domain that is phosphorylated on multiple sites by theExpand
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Characterization of the Rab8-specific membrane traffic route linked to protrusion formation
Rab8 has a drastic effect on cell shape, but the membrane trafficking route it regulates is poorly defined. Here, we show that endogenous and ectopically expressed Rab8 is associated withExpand
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FIP-2, a coiled-coil protein, links Huntingtin to Rab8 and modulates cellular morphogenesis
Huntington's disease is characterised by the death of cortical and striatal neurons, and is the result of an expanded polyglutamine tract in the Huntingtin protein [1]. Huntingtin is present on bothExpand
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VIP21/caveolin is a cholesterol-binding protein.
VIP21/caveolin is localized to both caveolae and apical transport vesicles and presumably cycles between the cell surface and the Golgi complex. We have studied the lipid interactions of this proteinExpand
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CP110 suppresses primary cilia formation through its interaction with CEP290, a protein deficient in human ciliary disease.
Primary cilia are nonmotile organelles implicated in signaling and sensory functions. Understanding how primary cilia assemble could shed light on the many human diseases caused by mutations inExpand
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The structure of the conserved neurotrophic factors MANF and CDNF explains why they are bifunctional.
We have solved the structures of mammalian mesencephalic astrocyte-derived neurotrophic factor (MANF) and conserved dopamine neurotrophic factor (CDNF). CDNF protects and repairs midbrainExpand
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