J. Pepin

Publications222
h-index35
Citations4,190
Highly Influential Citations173
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Cardiovascular consequences of sleep-disordered breathing: contribution of animal models to understanding the human disease.
Sleep-disordered breathing, and particularly the highly prevalent obstructive sleep apnea syndrome, is a multicomponent disorder combining intermittent hypoxia (IH), sleep fragmentation, and… Expand
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Improvement in quadriceps strength and dyspnea in daily tasks after 1 month of electrical stimulation in severely deconditioned and malnourished COPD.
STUDY OBJECTIVES Low body weight in COPD patients is associated with worsening dyspnea, reduced leg strength, and poor prognosis. Classical rehabilitation strategies are then limited by reduced… Expand
  • 177
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Mechanisms of cardiac dysfunction in obstructive sleep apnea
Obstructive sleep apnea (OSA) is associated with cardiovascular morbidity and mortality, largely as a result of myocardial anomalies. Numerous mechanisms cause OSA-related myocardial damage. The… Expand
  • 193
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Twenty-four hour (Nyctohemeral) rhythm of intraocular pressure and ocular perfusion pressure in normal-tension glaucoma.
PURPOSE To characterize the nyctohemeral rhythm of intraocular pressure (IOP) and ocular perfusion pressure (OPP) in patients with newly diagnosed, untreated normal tension glaucoma (NTG). METHODS… Expand
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Significant improvement in arterial stiffness after endurance training in patients with COPD.
BACKGROUND Arterial stiffness, a strong predictor of cardiovascular mortality, is abnormally elevated in patients with COPD. We investigated whether exercise training may decrease arterial stiffness… Expand
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Obstructive sleep apnoea syndrome
Nat. Rev. Dis. Primers article number: 15015; doi:10.1038/nrdp.2015.15; published online 25 June 2015 An extra affiliation for Dr Barbe has now been added: Respiratory Research Group, CIBERES,… Expand
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Mandibular advancement devices: rate of contraindications in 100 consecutive obstructive sleep apnea patients.
Mandibular advancement devices (MAD) should be contraindicated (Clark GT, Sleep Med Rev 1998;2:163-174) if there are: (1) insufficient teeth to support the device, (2) periodontal problems inducing… Expand
  • 154
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Impaired objective daytime vigilance in obesity-hypoventilation syndrome: impact of noninvasive ventilation.
BACKGROUND Obesity-hypoventilation syndrome (OHS) is efficiently treated by noninvasive ventilation (NIV). Sleep respiratory disturbances, reduced ventilatory drive, and excessive daytime sleepiness… Expand
  • 137
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Which memory processes are affected in patients with obstructive sleep apnea? An evaluation of 3 types of memory.
STUDY OBJECTIVE To investigate which memory processes are affected by obstructive sleep apnea (OSA). DESIGN Three separate memory systems were investigated in patients with OSA and normal subjects.… Expand
  • 96
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Definition, discrimination, diagnosis and treatment of central breathing disturbances during sleep
The complexity of central breathing disturbances during sleep has become increasingly obvious. They present as central sleep apnoeas (CSAs) and hypopnoeas, periodic breathing with apnoeas, or… Expand
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