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Molecular Cloning and Characterization of a Channel-like Transporter Mediating Intestinal Calcium Absorption*
TLDR
The properties of a calcium transport protein (CaT1) cloned from rat duodenum using an expression cloning strategy in Xenopus laevis oocytes are reported, which likely plays a key role in the intestinal uptake of calcium. Expand
Polycystin-2 is a novel cation channel implicated in defective intracellular Ca(2+) homeostasis in polycystic kidney disease.
TLDR
It is shown that PC2 is a Ca(2+)-permeable cation channel with properties distinct from any known intracellular channels, and that it can be translocated to the plasma membranes by defined chemical chaperones and proteasome modulators, suggesting that in vivo, it may also function in the plasma membrane under specific conditions. Expand
Human calcium transport protein CaT1.
TLDR
A role for hCaT1 in cellular calcium uptake in a variety of tissues, including the transcellular calcium transport pathway in intestine, is suggested. Expand
CaT1 expression correlates with tumor grade in prostate cancer.
TLDR
This work reports that the gene for CaT1, a channel protein highly selective for Ca(2+), is expressed at high levels in human PCa and in the LNCaP PCa cell line, and suggests thatCaT1 may be a novel target for therapy. Expand
A rat kidney-specific calcium transporter in the distal nephron.
TLDR
CaT2 may participate in calcium entry into the cells of the distal convoluted tubule and connecting segment of the nephron, where active reabsorption of calcium takes place via the transcellular route, and provides a potential explanation for Cd(2+)-induced hypercalciuria and resultant renal stone formation. Expand
Yeast SMF1 Mediates H+-coupled Iron Uptake with Concomitant Uncoupled Cation Currents*
TLDR
It is shown that SMF1 expressed in Xenopus oocytes mediates H+-dependent Fe2+ transport and uncoupled Na+ flux and proposed that uncoupling ion permeabilities in metal ion transporters protect cells from metal ion overload. Expand
Structural conservation of the genes encoding CaT1, CaT2, and related cation channels.
TLDR
The genomic structures of the genes encoding human calcium transport proteins CaT1 and CaT2, which belong to a recently identified class of highly selective calcium entry channels, are reported, concluding that ECAC2 and ECAC1, which encode calcium selective channels, share a common ancestral gene with the related nonselective cation channels. Expand
Transport function of the naturally occurring pathogenic polycystin-2 mutant, R742X.
TLDR
PC2 expressed heterologously in Xenopus oocytes is targeted to intracellular compartments and it is proposed that PC2 forms ion channels utilizing structural components which are preserved in the R742X form of the protein. Expand
Trpv6 mediates intestinal calcium absorption during calcium restriction and contributes to bone homeostasis.
TLDR
It is indicated that TRPV6 contributes to intestinal calcium transport when dietary calcium supply is limited and in this condition indirectly regulates bone formation and/or mineralization. Expand
Molecular cloning of canine bullous pemphigoid antigen 2 cDNA and immunomapping of NC16A domain by canine bullous pemphigoid autoantibodies.
TLDR
The cloning of the cDNA encoding this disease-associated protein may allow us to develop a canine model in dissecting the immunopathologic mechanism underlying bullous pemphigoid. Expand
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