• Publications
  • Influence
The K+/Cl− co-transporter KCC2 renders GABA hyperpolarizing during neuronal maturation
GABA (γ-aminobutyric acid) is the main inhibitory transmitter in the adult brain, and it exerts its fast hyperpolarizing effect through activation of anion (predominantly Cl−)-permeant GABAAExpand
  • 1,858
  • 173
Molecular Characterization of a Putative K-Cl Cotransporter in Rat Brain
Using a combination of data base searching, polymerase chain reaction, and library screening, we have identified a putative K-Cl cotransporter isoform (KCC2) in rat brain that is specificallyExpand
  • 517
  • 60
Mechanism of Activity-Dependent Downregulation of the Neuron-Specific K-Cl Cotransporter KCC2
GABA-mediated fast-hyperpolarizing inhibition depends on extrusion of chloride by the neuron-specific K-Cl cotransporter, KCC2. Here we show that sustained interictal-like activity in hippocampalExpand
  • 439
  • 47
  • PDF
Cation-chloride cotransporters in neuronal development, plasticity and disease
Electrical activity in neurons requires a seamless functional coupling between plasmalemmal ion channels and ion transporters. Although ion channels have been studied intensively for several decades,Expand
  • 370
  • 45
  • PDF
Functional characterization of the neuronal-specific K-Cl cotransporter: implications for [K+]o regulation.
  • J. Payne
  • Chemistry, Medicine
  • The American journal of physiology
  • 1 November 1997
The neuronal K-Cl cotransporter isoform (KCC2) was functionally expressed in human embryonic kidney (HEK-293) cell lines. Two stably transfected HEK-293 cell lines were prepared: one expressing anExpand
  • 211
  • 40
  • PDF
Functional characterization of the neuronal-specific K-Cl cotransporter: implications for [K+]oregulation.
  • J. Payne
  • Chemistry, Medicine
  • American journal of physiology. Cell physiology
  • 1 November 1997
The neuronal K-Cl cotransporter isoform (KCC2) was functionally expressed in human embryonic kidney (HEK-293) cell lines. Two stably transfected HEK-293 cell lines were prepared: one expressing anExpand
  • 318
  • 34
Direct Protein Kinase C-dependent Phosphorylation Regulates the Cell Surface Stability and Activity of the Potassium Chloride Cotransporter KCC2*
The potassium chloride cotransporter KCC2 plays a major role in the maintenance of transmembrane chloride potential in mature neurons; thus KCC2 activity is critical for hyperpolarizing membraneExpand
  • 228
  • 32
Molecular Cloning and Functional Expression of the K-Cl Cotransporter from Rabbit, Rat, and Human
We report the cloning, sequence analysis, tissue distribution, and functional expression of the K-Cl cotransport protein, KCC1. KCC1 was identified by searching the human expressed sequence tag dataExpand
  • 337
  • 30
The KCl cotransporter, KCC2, is highly expressed in the vicinity of excitatory synapses in the rat hippocampus
Immunocytochemical visualization of the neuron‐specific K+/Cl– cotransporter, KCC2, at the cellular and subcellular level revealed an area‐ and layer‐specific diffuse labelling, and a discreteExpand
  • 206
  • 27
The Neuron-specific K-Cl Cotransporter, KCC2
The neuron-specific K-Cl cotransporter (KCC2) is hypothesized to function as an active Cl− extrusion pathway important in postsynaptic inhibition mediated by ligand-gated anion channels, likeExpand
  • 225
  • 25