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Novel non-benzodiazepine anxiolytics
Benzodiazepine blockade of passive-avoidance task in mice: A state-dependent phenomenon
Results suggest that state-dependent learning occurred; i.e., apparent amnesia occurred in the test session with untreated mice that had undergone passive-avoidance learning 24 h earlier under the influence of drug.
Flunixin meglumine: a non-narcotic analgesic.
Results indicate that flunixin meglumine is a parenterally and orally effective analgesic in animals and is unlikely to have narcotic or drug dependence liability.
Synthesis and structure-activity relationships of a series of anxioselective pyrazolopyridine ester and amide anxiolytic agents.
A detailed pharmacological evaluation of one of the most potent behaviorally active compounds demonstrated it to be BZ1 selective; also, in comparison to diazepam, 27 showed minimal sedative and alcohol interactive properties at therapeutically effective doses.
Pharmacological properties of tracazolate: a new non-benzodiazepine anxiolytic agent.
Anti-nociceptive activity of clonixin in rhesus monkeys.
This investigation describes the analgesic properties of clonixin on behavior maintained by nociceptive electric shock in Rhesus monkeys (Macaca mulatta) using a shock-escape procedure.
Pharmacology of pyrazolopyridines
Neurotherapeutics: Emerging Strategies