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Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence
The complete genome sequence of the best-characterized strain of Mycobacterium tuberculosis, H37Rv, has been determined and analysed in order to improve the understanding of the biology of this slow-growing pathogen and to help the conception of new prophylactic and therapeutic interventions. Expand
A human gut microbial gene catalogue established by metagenomic sequencing
The Illumina-based metagenomic sequencing, assembly and characterization of 3.3 million non-redundant microbial genes, derived from 576.7 gigabases of sequence, from faecal samples of 124 European individuals are described, indicating that the entire cohort harbours between 1,000 and 1,150 prevalent bacterial species and each individual at least 160 such species. Expand
Artemis: sequence visualization and annotation
SUMMARY Artemis is a DNA sequence visualization and annotation tool that allows the results of any analysis or sets of analyses to be viewed in the context of the sequence and its six-frameExpand
Roary: rapid large-scale prokaryote pan genome analysis
Roary, a tool that rapidly builds large-scale pan genomes, identifying the core and accessory genes, is introduced, making construction of the pan genome of thousands of prokaryote samples possible on a standard desktop without compromising on the accuracy of results. Expand
Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2)
The 8,667,507 base pair linear chromosome of Streptomyces coelicolor is reported, containing the largest number of genes so far discovered in a bacterium. Expand
The genome sequence of the food-borne pathogen Campylobacter jejuni reveals hypervariable sequences
The genome sequence of C. jejuni NCTC11168 is reported, finding short homopolymeric runs of nucleotides were commonly found in genes encoding the biosynthesis or modification of surface structures, or in closely linked genes of unknown function. Expand
ACT: the Artemis comparison tool
The Artemis Comparison Tool (ACT) allows an interactive visualisation of comparisons between complete genome sequences and associated annotations and so inherits powerful searching and analysis tools. Expand
Reagent and laboratory contamination can critically impact sequence-based microbiome analyses
It is demonstrated that contaminating DNA is ubiquitous in commonly used DNA extraction kits and other laboratory reagents, varies greatly in composition between different kits and kit batches, and that this contamination critically impacts results obtained from samples containing a low microbial biomass. Expand
Genome sequence of Yersinia pestis, the causative agent of plague
The evidence of ongoing genome fluidity, expansion and decay suggests Y. pestis is a pathogen that has undergone large-scale genetic flux and provides a unique insight into the ways in which new and highly virulent pathogens evolve. Expand
Complete genome sequence of a multiple drug resistant Salmonella enterica serovar Typhi CT18
The genome sequence is sequenced of a S. typhi (CT18) that is resistant to multiple drugs, revealing the presence of hundreds of insertions and deletions compared with the Escherichia coli genome, ranging in size from single genes to large islands. Expand