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Prostaglandin H synthase expression is variable in human colorectal adenocarcinoma cell lines.
- J. Parker, M. Kaplon, C. Alvarez, G. Krishnaswamy
- Biology, Medicine
- Experimental cell research
- 10 October 1997
Evidence suggests that PGH synthase-2 is a possible candidate for a tumor suppressor gene at 1q23-qter, and is associated with increased adhesion to extracellular matrix components and a potential inhibition of proliferation through the production of prostaglandin E2. Expand
Formation of a prostaglandin A2-glutathione conjugate in L1210 mouse leukemia cells.
It is confirmed that conjugation of PGA2 to glutathione occurs in both cell types and mechanisms for its antiviral and antigrowth actions are suggested. Expand
Evidence of protein kinase C involvement in phorbol diester-stimulated arachidonic acid release and prostaglandin synthesis.
Evidence that the activation of protein kinase C caused by 12-O-tetradecanoylphorbol-13-acetate (TPA) is involved in the increased prostaglandin production induced by Madin-Darby canine kidney (MDCK) cells is reported. Expand
Proceedings: The effects of lithium, rubidium and caesium on the response of rats to tranylcypromine and alpha-methyl-p-tyrosine given separately or in combination.
Binding of interleukin 2 to gangliosides
- J. Parker, G. Caldini, C. Krishnamurti, P. Ahrens, H. Ankel
- Chemistry, Medicine
- FEBS letters
- 21 May 1984
It is concluded that IL2 bound to exogenous gangliosides is inactive and that the carbohydrate portion of the Ganglioside is crucial to its interaction with IL2. Expand
Antiviral effect of cyclopentenone prostaglandins on vesicular stomatitis virus replication.
The relative inhibition of VSV RNA polymerase in vitro by prostaglandins with different structures correlated to inhibition ofVSV replication in infected cells indicates that the same step in VSV replication is inhibited by prostglandins both in the in vitro RNA polymerases assay and in the infected cell. Expand
Prostaglandin A2 protein interactions and inhibition of cellular proliferation.
- J. Parker
- Biology, Medicine
- 1 November 1995
Prostaglandin A2-biotin provided a sensitive method to demonstrate binding of PGA2 to cellular proteins of 43, 50, and 56 kilodaltons in K562 erythroleukemia cells, and one or more of the PGA 2-binding proteins may be involved in the inhibition of cellular proliferation by PGA1. Expand
Ether lipids inhibit the effects of phorbol diester tumor promoters
Evidence is provided that the antineoplastic ether lipids inhibit the biochemical effects of the tumor promoter TPA in intact cells and indicate that this inhibition may have a role in their biological activities. Expand
Stimulation of arachidonic acid release and prostaglandin synthesis by bryostatin 1.
It is found that bryostatin 1 could inhibit the effect of TPA both in stimulation of arachidonic acid release and in the induction of prostaglandin H synthase. Expand
The role of noradrenaline, dopamine and 5-hydroxytryptamine in the hyperactivity response resulting from the administration of tranylcypromine to rats pretreated with lithium or rubidium
The hyperactivity syndrome seen in rats after the administration of LiCl or RbCl and Tc is dependent upon both 5HT and dopamine mechanisms. Expand